Detailed information of TA system TA190241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3611947..3613168
• Replicon: chromosome
• Accession: NZ_CP069337
• Organism: Pseudomonas aeruginosa strain E04

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: JQ456_RS16705
• Protein ID: WP_003102740.1
• Coordinates: 3612590..3613168 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQ456_RS16700
• Protein ID: WP_003088112.1
• Coordinates: 3611947..3612501 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ456_RS16675 (JQ456_16675)	3607515..3608066	+	552	WP_003102727.1	XRE family transcriptional regulator	-
JQ456_RS16680 (JQ456_16680)	3608063..3608461	-	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
JQ456_RS16685 (JQ456_16685)	3608474..3608797	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
JQ456_RS16690 (JQ456_16690)	3609128..3609589	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
JQ456_RS16695 (JQ456_16695)	3609594..3611789	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JQ456_RS16700 (JQ456_16700)	3611947..3612501	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
JQ456_RS16705 (JQ456_16705)	3612590..3613168	+	579	WP_003102740.1	HD domain-containing protein	Toxin
JQ456_RS16710 (JQ456_16710)	3613277..3614464	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JQ456_RS16715 (JQ456_16715)	3614454..3616625	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
JQ456_RS16720 (JQ456_16720)	3616615..3617892	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T190241 WP_003102740.1 NZ_CP069337:3612590-3613168 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T190241 NZ_CP091198:725955-726299 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTAAACAAACGCGCATGTTTCGA
CCCTACTTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAATTTATTTGAAGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT190241 WP_003088112.1 NZ_CP069337:3611947-3612501 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT190241 NZ_CP091198:725601-725936 [Enterococcus faecalis]
ATGACAGTGTTTGATAGGATCAAATTATTAGCAAAAGAGAGAGGAAAATCCTTAAATCGAATCGAAGAAGAATTAGGTTT
ACCAAAAAATGTTCTGTATCGTATGAAAACTTCCGATAATCCTACTAAAGATAGACTAGAAACTTTAGCTAATTACTTTG
ATGTATCTGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAAATCTGATGATTTAGATGAT
GTACTGGATAACGTCATGAGCTTTGACGGTAAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGG
TAGATTCGGGAAATAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07