Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 180490..180995 Replicon chromosome
Accession NZ_CP069337
Organism Pseudomonas aeruginosa strain E04

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag JQ456_RS00920 Protein ID WP_003121619.1
Coordinates 180490..180771 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag JQ456_RS00925 Protein ID WP_003112628.1
Coordinates 180768..180995 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ456_RS00895 (JQ456_00895) 175741..177090 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
JQ456_RS00900 (JQ456_00900) 177139..177825 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
JQ456_RS00905 (JQ456_00905) 177926..178660 + 735 WP_003101224.1 GntR family transcriptional regulator -
JQ456_RS00910 (JQ456_00910) 178840..179250 + 411 WP_003101225.1 aegerolysin family protein -
JQ456_RS00915 (JQ456_00915) 179282..180190 - 909 WP_003083769.1 LysR family transcriptional regulator -
JQ456_RS00920 (JQ456_00920) 180490..180771 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
JQ456_RS00925 (JQ456_00925) 180768..180995 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
JQ456_RS00930 (JQ456_00930) 181171..181791 - 621 WP_003101226.1 hypothetical protein -
JQ456_RS00935 (JQ456_00935) 181892..182392 + 501 WP_003112629.1 LEA type 2 family protein -
JQ456_RS00940 (JQ456_00940) 182465..182806 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
JQ456_RS00945 (JQ456_00945) 182888..184315 - 1428 WP_003083784.1 GABA permease -
JQ456_RS00950 (JQ456_00950) 184484..185977 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T190239 WP_003121619.1 NZ_CP069337:c180771-180490 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T190239 NZ_CP091197:34246-34515 [Enterococcus faecalis]
ATGTCCTATCGATTAGAATTTACTCCTGATGTAAAAAAACAGTTAAAAAAAATGGATAAATATCAAGCGACATTGCTAAC
AAGATGGTTGTATCGAAATATTGATGGAACGGCCAATCCTAGAGAGCATGGAAAAGCTTTATCAGCAAATCGTGCAGGTC
AGTGGCGATATAGGATAGGGAATTATCGTGTCATTGTAGAAATAGAAGATGAACGTCTTGTTGTTACAGCCATTCAGGTT
GGCCACAGAAGAAATGTTTACGACAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT190239 WP_003112628.1 NZ_CP069337:c180995-180768 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT190239 NZ_CP091197:34025-34246 [Enterococcus faecalis]
ATGATTACTGTAAGAGTGAGTGATGAAGAAAAAGAATGGCTTTCTTACATGGCAGAATTTTTCGGTGTGACGTTGTCGGA
TTTGTTAAAAAGCTATTCAATGGAACAATTAGAAGATGAGTACGATAAACAAACAGCAGAAATTGCTCACAAACGATGGA
TTGAGCAAGGAAAAGAAACAATTTCTATGGACGAAATATTAAATGAGTTTGGTGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References