Detailed information of TA system TA190236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3532822..3534043
• Replicon: chromosome
• Accession: NZ_CP069336
• Organism: Pseudomonas aeruginosa strain E01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: JQ453_RS16285
• Protein ID: WP_003102740.1
• Coordinates: 3533465..3534043 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQ453_RS16280
• Protein ID: WP_003088112.1
• Coordinates: 3532822..3533376 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ453_RS16255 (JQ453_16255)	3528390..3528941	+	552	WP_004343115.1	XRE family transcriptional regulator	-
JQ453_RS16260 (JQ453_16260)	3528938..3529336	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
JQ453_RS16265 (JQ453_16265)	3529349..3529672	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
JQ453_RS16270 (JQ453_16270)	3530003..3530464	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
JQ453_RS16275 (JQ453_16275)	3530469..3532664	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JQ453_RS16280 (JQ453_16280)	3532822..3533376	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
JQ453_RS16285 (JQ453_16285)	3533465..3534043	+	579	WP_003102740.1	HD domain-containing protein	Toxin
JQ453_RS16290 (JQ453_16290)	3534152..3535339	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JQ453_RS16295 (JQ453_16295)	3535329..3537500	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
JQ453_RS16300 (JQ453_16300)	3537490..3538767	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T190236 WP_003102740.1 NZ_CP069336:3533465-3534043 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T190236 NZ_CP091187:c42397-42101 [Vibrio anguillarum]
ATGTTCACTATAAAGCGCACGCAACTTTTTGATGATTGGTTGAAGACACTTAAAGATGCTCAGGCACGAGGTGCTATCAC
TGCTCGTGTTCAGCGCCTTACTCAGGGTTTGAGTGGGGATGTTAAGCCGGTTGGTTCGGGCATTAGTGAGCTTAGGATAC
ATGTCGGTAAAGGTTATCGAGTTTATTTTAAGCGTAGTGGAAAACAGATCGTTGTCTTACTTTGCGGTGGCAATAAGAAA
ACTCAGAATCAAGATATCGAACGCGCTAAAGAGTTGGTTCAATATTTTGATTTGTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT190236 WP_003088112.1 NZ_CP069336:3532822-3533376 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT190236 NZ_CP091187:c42077-41787 [Vibrio anguillarum]
ATGAATATTACCAGGCTCGATGATTTTGATCCTGCTGACTATCTTGATAATGCTGAATCTATACAGGCATATATTGATGA
GGCGGTAGCAACTGGTGATGCTGCTTTTATTAGTCAATCCTTGGGTGTTATAGCCCGTGCCAAAGGTATGAATACGCTAG
CAGAGGAAACCGGTTTATCTCGTGAAACTTTATATAGAACATTAAGCGTTAAAGGGAATCCTAACCTTAAAACGCTTATC
TCTATCACTAATGCGCTTGGTGTATCTGTCAAACTCGGCTCTTACTGTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07