Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1568826..1570521 | Replicon | chromosome |
| Accession | NZ_CP069336 | ||
| Organism | Pseudomonas aeruginosa strain E01 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | JQ453_RS07315 | Protein ID | WP_003112901.1 |
| Coordinates | 1568826..1569695 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | JQ453_RS07320 | Protein ID | WP_003112902.1 |
| Coordinates | 1569688..1570521 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JQ453_RS07290 (JQ453_07270) | 1564834..1565685 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| JQ453_RS07295 (JQ453_07275) | 1565726..1566733 | + | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| JQ453_RS07300 (JQ453_07280) | 1566730..1567506 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| JQ453_RS07305 (JQ453_07285) | 1567512..1568273 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| JQ453_RS07310 (JQ453_07290) | 1568287..1568817 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| JQ453_RS07315 (JQ453_07295) | 1568826..1569695 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| JQ453_RS07320 (JQ453_07300) | 1569688..1570521 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| JQ453_RS07325 (JQ453_07305) | 1570508..1571305 | + | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| JQ453_RS07330 (JQ453_07310) | 1571298..1572980 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| JQ453_RS07335 (JQ453_07315) | 1572991..1573794 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| JQ453_RS07340 (JQ453_07320) | 1573806..1575290 | + | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T190234 WP_003112901.1 NZ_CP069336:1568826-1569695 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T190234 NZ_CP091186:c221142-220645 [Vibrio anguillarum]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT190234 WP_003112902.1 NZ_CP069336:1569688-1570521 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
>AT190234 NZ_CP091186:c221411-221139 [Vibrio anguillarum]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|