Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 142973..143478 | Replicon | chromosome |
| Accession | NZ_CP069336 | ||
| Organism | Pseudomonas aeruginosa strain E01 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | V6A7K8 |
| Locus tag | JQ453_RS00660 | Protein ID | WP_003083773.1 |
| Coordinates | 142973..143254 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A1C7BDS9 |
| Locus tag | JQ453_RS00665 | Protein ID | WP_003083775.1 |
| Coordinates | 143251..143478 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JQ453_RS00635 (JQ453_00635) | 138224..139573 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
| JQ453_RS00640 (JQ453_00640) | 139622..140308 | + | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
| JQ453_RS00645 (JQ453_00645) | 140409..141143 | + | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
| JQ453_RS00650 (JQ453_00650) | 141323..141733 | + | 411 | WP_003101225.1 | aegerolysin family protein | - |
| JQ453_RS00655 (JQ453_00655) | 141765..142673 | - | 909 | WP_010793581.1 | LysR family transcriptional regulator | - |
| JQ453_RS00660 (JQ453_00660) | 142973..143254 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
| JQ453_RS00665 (JQ453_00665) | 143251..143478 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| JQ453_RS00670 (JQ453_00670) | 143654..144274 | - | 621 | WP_003101226.1 | hypothetical protein | - |
| JQ453_RS00675 (JQ453_00675) | 144375..144875 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
| JQ453_RS00680 (JQ453_00680) | 144948..145289 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
| JQ453_RS00685 (JQ453_00685) | 145371..146798 | - | 1428 | WP_003083784.1 | GABA permease | - |
| JQ453_RS00690 (JQ453_00690) | 146967..148460 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T190233 WP_003083773.1 NZ_CP069336:c143254-142973 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T190233 NZ_CP091186:161318-161851 [Vibrio anguillarum]
GTGAGTTGGGGCAGAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGGTCAAC
CGCTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGACA
CAGTTAGCAAAGAAACTACCGAGATATCCAATCCCTGTTTTTCTGTTGGCTCAATTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTAAATCATCACATGAGGGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTACTTACCGATGAAAACGGTAGAACAGCTTTTTAATCAATAG
GTGAGTTGGGGCAGAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGGTCAAC
CGCTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGACA
CAGTTAGCAAAGAAACTACCGAGATATCCAATCCCTGTTTTTCTGTTGGCTCAATTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTAAATCATCACATGAGGGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTACTTACCGATGAAAACGGTAGAACAGCTTTTTAATCAATAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT190233 WP_003083775.1 NZ_CP069336:c143478-143251 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT190233 NZ_CP091186:160890-161321 [Vibrio anguillarum]
GTGTTTACAGTGTGTTTTTTGAGTTCGGCGGTGCGTTGTCAACCCCTTAGCCGGGCGTTATATTCTCCCTCGTTCCGTAA
ACTTTCCGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTATGCAGGAGGGG
TTATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGC
TTAAAAAGTCTCACTGAATACGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTAT
GGTTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTG
TTAAATTTACAGAGAAGAGCGGTATCAAGTGA
GTGTTTACAGTGTGTTTTTTGAGTTCGGCGGTGCGTTGTCAACCCCTTAGCCGGGCGTTATATTCTCCCTCGTTCCGTAA
ACTTTCCGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTATGCAGGAGGGG
TTATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGC
TTAAAAAGTCTCACTGAATACGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTAT
GGTTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTG
TTAAATTTACAGAGAAGAGCGGTATCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|