Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1837779..1839287 Replicon chromosome
Accession NZ_CP069335
Organism Pseudomonas aeruginosa strain E02

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag JQ454_RS08570 Protein ID WP_003119682.1
Coordinates 1837779..1838366 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag JQ454_RS08575 Protein ID WP_003091607.1
Coordinates 1838433..1839287 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ454_RS08565 (JQ454_08555) 1834034..1837513 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
JQ454_RS08570 (JQ454_08560) 1837779..1838366 + 588 WP_003119682.1 GNAT family protein Toxin
JQ454_RS08575 (JQ454_08565) 1838433..1839287 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
JQ454_RS08580 (JQ454_08570) 1839384..1841549 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
JQ454_RS08585 (JQ454_08575) 1841724..1843598 + 1875 WP_010793244.1 MFS transporter -
JQ454_RS08590 (JQ454_08580) 1843659..1843868 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T190229 WP_003119682.1 NZ_CP069335:1837779-1838366 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T190229 NZ_CP091181:c5100-4792 [Aeromonas caviae]
ATGCAGTTCACTATCTACCGCAACAAGGGCAATGCCCGCGCTTACCCCTATTTGCTGGATGTGCAAAGCGACATCATTGG
CGAGCTGGCCACCAGGATGGTGATCCCACTGTTCCCGCTGGTAGCCTTCACTGGACGGCCAGCGCAGCGGCTGAATCCGG
TGATCATCGTTGAGGGTGATAAGTATTTGGTGATGACGCAGGACATGGCAGCGGTGAGGCTGGCGCAGCTTGGGGATGAA
GTCACTGGTGTGCAGGAGTCGCGTCAGCTCATCAAGGACGCGATAGATTTCTTGTTTGATGGTGTGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT190229 WP_003091607.1 NZ_CP069335:1838433-1839287 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT190229 NZ_CP091181:c5339-5100 [Aeromonas caviae]
ATGGTCGCAGCAGCAATGCGCAGCAAGAGAACGGTCAGCGTCACGCTGGAGCCCAGCTTGTTGGAACGAGCCAGAGCGGC
GGGGATCAACCTGTCAGCCACCCTTGCAACCGCGCTACAGAATGAAATCAGCGGCTCAGAAGCAGAACGCTGGAAGCGTG
AGAACAGTGCAGCCATACAGACGCTGAACCGCATCACCGAGGAGCACGGCCTGCTCTCCGACGATTACAGGGCGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References