190223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1837774..1839282 Replicon chromosome
Accession NZ_CP069334
Organism Pseudomonas aeruginosa strain E03

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag JQ455_RS08570 Protein ID WP_003119682.1
Coordinates 1837774..1838361 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag JQ455_RS08575 Protein ID WP_003091607.1
Coordinates 1838428..1839282 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ455_RS08565 (JQ455_08555) 1834029..1837508 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
JQ455_RS08570 (JQ455_08560) 1837774..1838361 + 588 WP_003119682.1 GNAT family protein Toxin
JQ455_RS08575 (JQ455_08565) 1838428..1839282 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
JQ455_RS08580 (JQ455_08570) 1839379..1841544 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
JQ455_RS08585 (JQ455_08575) 1841719..1843593 + 1875 WP_010793244.1 MFS transporter -
JQ455_RS08590 (JQ455_08580) 1843654..1843863 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T190223 WP_003119682.1 NZ_CP069334:1837774-1838361 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T190223 NZ_CP091174:3381025-3381303 [Stutzerimonas stutzeri]
ATGATCAAAACGTTCCAGCACAAAGGGCTTCGCAAGCTCTTCGAAACCGGCAGCACGGCCGGCGTACAGCCAGCCCATGC
CAAGCGGCTACGGATGCAACTGGCGGCCCTGGATACGGCCATGACGATAGACGACATGGATATCCCCGGCTTCCGGCTGC
ACCCGCTCAAGGGCGAAATGCGGGGGCGCTGGTCGATCATGGTGAACGGCAACTGGCGGCTGACGTTCGAGTTTCGCGAC
GGAAACGCTTATGTCCTGGACTATGAGGATTACCACTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT190223 WP_003091607.1 NZ_CP069334:1838428-1839282 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT190223 NZ_CP091174:3381303-3381590 [Stutzerimonas stutzeri]
ATGAGCATGCACAACCCTCCCCATCCTGGTGAGTTCATCACCGATATCTACCTGGAGCCGAACGGCATCAGCGGCCGTGA
GCTGGCGGAAAAGCTCGGCGTTGCACCCTCTACCCTGAGCCGAGTTTTGAAGGGCACCAGTCGCGTCACGCCGGAAATGG
CACTGCGCCTGTCGGTAGCGCTTGGCCGCTCGCCTGAGAGCTGGCTGGCCATGCAGGATACCTACGATCTGTGGGTTGCT
CGTCAGCATGTGGATCTGCAGCATGTTGGCAAATTGGCCTTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References