Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4910303..4911811 Replicon chromosome
Accession NZ_CP069332
Organism Pseudomonas aeruginosa strain R08

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag JQ464_RS22805 Protein ID WP_003119682.1
Coordinates 4911224..4911811 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag JQ464_RS22800 Protein ID WP_003091607.1
Coordinates 4910303..4911157 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ464_RS22785 (JQ464_22760) 4905722..4905931 + 210 WP_003091604.1 cold-shock protein -
JQ464_RS22790 (JQ464_22765) 4905992..4907866 - 1875 WP_010793244.1 MFS transporter -
JQ464_RS22795 (JQ464_22770) 4908041..4910206 - 2166 WP_010793245.1 TonB-dependent receptor family protein -
JQ464_RS22800 (JQ464_22775) 4910303..4911157 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
JQ464_RS22805 (JQ464_22780) 4911224..4911811 - 588 WP_003119682.1 GNAT family protein Toxin
JQ464_RS22810 (JQ464_22785) 4912077..4915556 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T190213 WP_003119682.1 NZ_CP069332:c4911811-4911224 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T190213 NZ_CP091147:4548032-4548313 [Pseudomonas avellanae]
ATGCTGGTTGAGTGGCGGCCGGCAGCACGAATTAACCTGCAGCAAATACCTCTCTACATTGCAGACAGAAACGCACAAGC
AGCCAGCGAGCTGGGAATGGCGATAGAAGTAGCCACCTCAGCTCTCCCGCAACACCCTTGCTTGTACCGCCAAGGGCGAG
TGCCTGGAACCCGGGAAATCGTTGTCCACCCCAATTATCTCGTTGTGTACCGAGTGACAGATCGGATCGAAGTTCTCGCA
GTGCTTCACGCAAGGCATGCCTACCCTACCGACGCCGGGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT190213 WP_003091607.1 NZ_CP069332:c4911157-4910303 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT190213 NZ_CP091147:4547851-4548042 [Pseudomonas avellanae]
ATGAGCGCTCGAACTTCTCCAATCGTGTCGGAGTTTAAAACTGAGGAACAGGCCGCCAGCTACGACAAATGGTTTCGTGC
CCAGGTGCAGGCTTCAATCAGTGATCCAGCGCCAAATATTCCACACGATCAGGTCATGGCCGAGATGCGTGAATTTCTAG
AGTCGAAGCAGACTCCGTCAGATGCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References