190210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142956..143461 Replicon chromosome
Accession NZ_CP069332
Organism Pseudomonas aeruginosa strain R08

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag JQ464_RS00660 Protein ID WP_003083773.1
Coordinates 142956..143237 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag JQ464_RS00665 Protein ID WP_003083775.1
Coordinates 143234..143461 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ464_RS00635 (JQ464_00635) 138207..139556 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
JQ464_RS00640 (JQ464_00640) 139605..140291 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
JQ464_RS00645 (JQ464_00645) 140392..141126 + 735 WP_003117208.1 GntR family transcriptional regulator -
JQ464_RS00650 (JQ464_00650) 141306..141716 + 411 WP_003101225.1 aegerolysin family protein -
JQ464_RS00655 (JQ464_00655) 141748..142656 - 909 WP_010793581.1 LysR family transcriptional regulator -
JQ464_RS00660 (JQ464_00660) 142956..143237 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
JQ464_RS00665 (JQ464_00665) 143234..143461 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
JQ464_RS00670 (JQ464_00670) 143637..144257 - 621 WP_003101226.1 hypothetical protein -
JQ464_RS00675 (JQ464_00675) 144358..144858 + 501 WP_003101228.1 LEA type 2 family protein -
JQ464_RS00680 (JQ464_00680) 144931..145272 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
JQ464_RS00685 (JQ464_00685) 145354..146781 - 1428 WP_003083784.1 GABA permease -
JQ464_RS00690 (JQ464_00690) 146950..148443 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T190210 WP_003083773.1 NZ_CP069332:c143237-142956 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T190210 NZ_CP091147:4256205-4256555 [Pseudomonas avellanae]
ATGAATACGTTTGCACTACGCTTTACCGATGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCATCTGGCTATCACTCA
GGGATTCTCATCAGCTGCTCAACGCATAGATACCCTGATCGATGCCATTCAGGACAAGCTCCTGTCCACCCCGTTGGGCC
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGCGTACTTCACTATCGTGAGTTGAACACAGACGGATACCGGATCTTTTAT
GAGGTGATGGATTCTGATGGTATTACCGACATCGCCGTATTGCTCGTATTAGGCGGGAAACAAAGTGTGGAGCAGGCTCT
GATCCGCTACTGCCTGCTCCAGCCGATGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT190210 WP_003083775.1 NZ_CP069332:c143461-143234 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT190210 NZ_CP091147:4255944-4256192 [Pseudomonas avellanae]
ATGCGAGTTGAAACAATAAGTTATCTGAAACGCAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTCCCGGCCTATGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAATCGATCGCCTTGGTGAAACTCCTGG
CGATCAGTTCCCGCGAGTACGCCCAAGGCAAGCACTGCTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTGCC
CACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References