Detailed information of TA system TA190209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 5179365..5181060
• Replicon: chromosome
• Accession: NZ_CP069331
• Organism: Pseudomonas aeruginosa strain R09

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9HYA0
• Locus tag: JQ465_RS24075
• Protein ID: WP_003112901.1
• Coordinates: 5180191..5181060 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: JQ465_RS24070
• Protein ID: WP_003112902.1
• Coordinates: 5179365..5180198 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ465_RS24050 (JQ465_24020)	5174596..5176080	-	1485	WP_003453562.1	aldehyde dehydrogenase	-
JQ465_RS24055 (JQ465_24025)	5176092..5176895	-	804	WP_003130116.1	aspartate dehydrogenase	-
JQ465_RS24060 (JQ465_24030)	5176906..5178588	-	1683	WP_003130114.1	thiamine pyrophosphate-binding protein	-
JQ465_RS24065 (JQ465_24035)	5178581..5179378	-	798	WP_003112903.1	SDR family oxidoreductase	-
JQ465_RS24070 (JQ465_24040)	5179365..5180198	-	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
JQ465_RS24075 (JQ465_24045)	5180191..5181060	-	870	WP_003112901.1	alpha/beta hydrolase	Toxin
JQ465_RS24080 (JQ465_24050)	5181069..5181599	-	531	WP_003112900.1	cupin domain-containing protein	-
JQ465_RS24085 (JQ465_24055)	5181613..5182374	-	762	WP_003112899.1	SDR family oxidoreductase	-
JQ465_RS24090 (JQ465_24060)	5182380..5183156	-	777	WP_003112898.1	ABC transporter permease	-
JQ465_RS24095 (JQ465_24065)	5183153..5184160	-	1008	WP_003112897.1	ABC transporter substrate-binding protein	-
JQ465_RS24100 (JQ465_24070)	5184201..5185052	-	852	WP_003130104.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30403.60 Da
• Isoelectric Point: 6.5894

>T190209 WP_003112901.1 NZ_CP069331:c5181060-5180191 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T190209 NZ_CP091147:c2380226-2379942 [Pseudomonas avellanae]
CTGCAGGTTGAATGGCTAAAAACAGCATTAAAAAACCTGGATGATAAAGCCGCCTACATCTCGCTAGAAAATCCGGCTGC
TGCGGTTGTTTTCGTAGAAGCAATACAAATAAGCGTAAAGCAGCTCGCAAGCTTTCCGGCCCTAGGCCGAGAGGGACGAA
TTGCTGGCTCCAGAGAATGGCCTTTGCCAGACTGGCCTTACCTGATTCCATACCGCATCCGTAACGGCCGCTTACAGGTT
CTGCGGATTTTCCACATGAGAAGGCAGCCGCCGTTGGTGTGGTAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT190209 WP_003112902.1 NZ_CP069331:c5180198-5179365 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

>AT190209 NZ_CP091147:c2380455-2380216 [Pseudomonas avellanae]
ATGTCCGTTATGTCTCTACGCCTGCCGGACGAGATGGCAGATACCCTTGCACACCTCGGCAAAGCGACCGGCCGCAGCAA
GTCGTTTTTGGCCCTGAACGCATTACGTGAATACTTGACTCGCGAAGCCTGGCAGATTGCCGAAATTCAGCGTGCAATTG
AAGAAGCAGACGCGGGCGAGTTTGCAAGTGAAGAAGATGTAAAGGCAGTGATGAATAAATGGGCGAACACTGCAGGTTGA

Structures

Toxin

• AlphaFold DB: Q9HYA0

Antitoxin

• AlphaFold DB: Q9HYA1