Detailed information of TA system TA190206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2361642..2362900
• Replicon: chromosome
• Accession: NZ_CP069331
• Organism: Pseudomonas aeruginosa strain R09

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: JQ465_RS10990
• Protein ID: WP_003112528.1
• Coordinates: 2362145..2362900 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JQ465_RS10985
• Protein ID: WP_003086329.1
• Coordinates: 2361642..2362010 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ465_RS10965 (JQ465_10950)	2357805..2358080	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
JQ465_RS10970 (JQ465_10955)	2358083..2358559	-	477	WP_003112531.1	hypothetical protein	-
JQ465_RS10975 (JQ465_10960)	2358734..2360227	+	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
JQ465_RS10980 (JQ465_10965)	2360283..2361569	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
JQ465_RS10985 (JQ465_10970)	2361642..2362010	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JQ465_RS10990 (JQ465_10975)	2362145..2362900	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
JQ465_RS10995 (JQ465_10980)	2363668..2365029	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
JQ465_RS11000 (JQ465_10985)	2365184..2367727	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T190206 WP_003112528.1 NZ_CP069331:2362145-2362900 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T190206 NZ_CP091147:62263-62445 [Pseudomonas avellanae]
ATGAAGTGCAGCGAGTTTCGGCGATGGTTACAGGCTCAAGGCGCTGAGTTCAAAGCGGCCAAGGGCAGCCACTTCAAGGT
GTACTTGAATGGCAAGGCGACCATCTTTGCGGACCACGGCAGCAAGGAAATGCACGAAGGGTTACGTAAATCGATCATCA
AACAGCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT190206 WP_003086329.1 NZ_CP069331:2361642-2362010 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT190206 NZ_CP091147:62478-62903 [Pseudomonas avellanae]
ATGTATCAGTACCCGTTAGAACTGCATCAGGAACCAACCGGCATCTGGTTGTCATGCCCGGATATTCCCGAAATGAACGC
CTCGGGTGACACCTTGGACGAGGCGCTGGCCGAAGCCCTGAACGGCATGGAGTCGGCCTTTTCGCTCTACGTTGACCAGC
GCCGCAAGATCCCGCAGGCGTCGCTGCCATCCGGCGATGAGTTGGTGATGCACCTGCCTGCGCTGACTGTCGCCAAGATC
ATGCTGTGGAACAGCATGTTGGACAATGGCGTGAGCCGGGCCGAACTGGCGCGCCGTCTGAGCTGTACGCGGCAAGTTGT
GGATCGGCTGGTGGACTTCCTGCACACCTCGAAAATCGAGCAGGTGGAGCGGGCATTGGCTGTGCTGGGTCGGCGCATAA
CGTTGAGCATTGAGCAGGCTGCGTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7