Detailed information of TA system TA190202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4386903..4388161
• Replicon: chromosome
• Accession: NZ_CP069330
• Organism: Pseudomonas aeruginosa strain R07

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: JQ463_RS20400
• Protein ID: WP_003112528.1
• Coordinates: 4386903..4387658 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JQ463_RS20405
• Protein ID: WP_003086329.1
• Coordinates: 4387793..4388161 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ463_RS20390 (JQ463_20365)	4382076..4384619	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
JQ463_RS20395 (JQ463_20370)	4384774..4386135	-	1362	WP_010895536.1	DNA recombination protein RmuC	-
JQ463_RS20400 (JQ463_20375)	4386903..4387658	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
JQ463_RS20405 (JQ463_20380)	4387793..4388161	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JQ463_RS20410 (JQ463_20385)	4388234..4389520	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
JQ463_RS20415 (JQ463_20390)	4389576..4391069	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
JQ463_RS20420 (JQ463_20395)	4391244..4391720	+	477	WP_003112531.1	hypothetical protein	-
JQ463_RS20425 (JQ463_20400)	4391723..4391998	-	276	WP_010793902.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T190202 WP_003112528.1 NZ_CP069330:c4387658-4386903 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T190202 NZ_CP091145:c69310-68894 [Pseudomonas avellanae]
ATGATCGTCCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGTCCCACTTGGCCGTGCGGGCCTGGCTGAACGA
TCAAGCCGCCGAAACGCTATACCTGTCCAGCGTGACGCTGGCTGAGCTGCTGTTTGGCATCGGGGCGCTCCCGGCCGGCA
AGCGCAAGGACATGCTGGCGCAGGCTCTTGACGGTCTAATGGGGCTGTTCAGGGATCGGGGGCTGCCATTCGATATCGAT
GCAGCACGGCGCTATGCCGATCTGGCCGTGACGGCAAAAACCTGCGGGCGAGGATTCCCGACACCTGACGGCTACATCGC
AGCGATTGCGGCATCGCGAGGTTTCATCGTGGCGTCACGCGACACTGCACCCTATGAGGCGGTCGGTGTATCCGTCATCA
ATCCGTGGGAAGTGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT190202 WP_003086329.1 NZ_CP069330:c4388161-4387793 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT190202 NZ_CP091145:c69561-69307 [Pseudomonas avellanae]
ATGGCAATGCTGACAGTACGGAACTTGCCCGACGATGTACACCGCGCGCTACGAGTGCGGGCCGCCCAACACGGGCACAG
CACCGAGGCCGAAGTCCGCGAGATTCTGGCGATCGCAGTCAAGCCGGAGACGCGCGTTCGCCTAGGTGAAGCCTTGGCGG
CATTGGGTCGCAAGATCGGCCTGACGAACGAAGATTTCGAGGTCTTCAACCAAGTGCGAGACAAGACGCCGGCCAAGCCG
CTGAGGTTTGAATGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7