Detailed information of TA system TA190198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142952..143457
• Replicon: chromosome
• Accession: NZ_CP069330
• Organism: Pseudomonas aeruginosa strain R07

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: JQ463_RS00660
• Protein ID: WP_003083773.1
• Coordinates: 142952..143233 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: JQ463_RS00665
• Protein ID: WP_003083775.1
• Coordinates: 143230..143457 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ463_RS00635 (JQ463_00635)	138203..139552	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
JQ463_RS00640 (JQ463_00640)	139601..140287	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
JQ463_RS00645 (JQ463_00645)	140388..141122	+	735	WP_003117208.1	GntR family transcriptional regulator	-
JQ463_RS00650 (JQ463_00650)	141302..141712	+	411	WP_003101225.1	aegerolysin family protein	-
JQ463_RS00655 (JQ463_00655)	141744..142652	-	909	WP_010793581.1	LysR family transcriptional regulator	-
JQ463_RS00660 (JQ463_00660)	142952..143233	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
JQ463_RS00665 (JQ463_00665)	143230..143457	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
JQ463_RS00670 (JQ463_00670)	143633..144253	-	621	WP_003101226.1	hypothetical protein	-
JQ463_RS00675 (JQ463_00675)	144354..144854	+	501	WP_003101228.1	LEA type 2 family protein	-
JQ463_RS00680 (JQ463_00680)	144927..145268	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
JQ463_RS00685 (JQ463_00685)	145350..146777	-	1428	WP_003083784.1	GABA permease	-
JQ463_RS00690 (JQ463_00690)	146946..148439	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T190198 WP_003083773.1 NZ_CP069330:c143233-142952 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T190198 NZ_CP091143:c5916632-5916351 [Pseudomonas avellanae]
ATGAGAGAGTTGAAGGTTTTCGAAGCTTCTGACTACCTGAACAACGACGAGGAAATTGCCGAGTTTCTGAGCATTTCCCT
GGAAGACCCAAACCCTGACGTTTTCCTCAGGGCTTTGCAGGAAGTCGCGAAGGCGCGTGGAATGAGCCAGCTTGCCCGTG
ACGCTGGCATCAATCGCGAATCGCTCTACAAAGCTTTGACGCCAGGTGCAAAGCCTCGGTATGACACGGTTTTGAAGGTG
ATGAATGCGTTAGGTATGAAGCTGACCGCCCAGCACGTATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT190198 WP_003083775.1 NZ_CP069330:c143457-143230 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT190198 NZ_CP091143:c5916937-5916629 [Pseudomonas avellanae]
ATGAACACACTCATCAGAACCCACGAATTCGACGCATGGCTGAAAGGCTTGAAGGACGTAACGGCGCGCCTGAGAATCCT
GAACCGTATCATGGCGGCACAGGAAGGCAACTTTGGGGACTGCGAACCTGTCGGGCACGGCATCAGTGAAATGCGCATCT
TCGTAGGACCTGGCTACCGTGTGTACTACACCAGGCGCGCAGAAGTGGTCTATCTGCTACTGTGTGGCGGCAACAAGTCC
TCACAGAAGCGCGACATAAAGCTGGCGAAATCCATCCTCGATGAGATCGAGAAAGGAGACGTAGAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9