Detailed information of TA system TA190197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 5177649..5179344
• Replicon: chromosome
• Accession: NZ_CP069329
• Organism: Pseudomonas aeruginosa strain R10

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9HYA0
• Locus tag: JQ466_RS24075
• Protein ID: WP_003112901.1
• Coordinates: 5178475..5179344 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: JQ466_RS24070
• Protein ID: WP_003112902.1
• Coordinates: 5177649..5178482 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ466_RS24050 (JQ466_24025)	5172880..5174364	-	1485	WP_003453562.1	aldehyde dehydrogenase	-
JQ466_RS24055 (JQ466_24030)	5174376..5175179	-	804	WP_003130116.1	aspartate dehydrogenase	-
JQ466_RS24060 (JQ466_24035)	5175190..5176872	-	1683	WP_003130114.1	thiamine pyrophosphate-binding protein	-
JQ466_RS24065 (JQ466_24040)	5176865..5177662	-	798	WP_003112903.1	SDR family oxidoreductase	-
JQ466_RS24070 (JQ466_24045)	5177649..5178482	-	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
JQ466_RS24075 (JQ466_24050)	5178475..5179344	-	870	WP_003112901.1	alpha/beta hydrolase	Toxin
JQ466_RS24080 (JQ466_24055)	5179353..5179883	-	531	WP_003112900.1	cupin domain-containing protein	-
JQ466_RS24085 (JQ466_24060)	5179897..5180658	-	762	WP_003112899.1	SDR family oxidoreductase	-
JQ466_RS24090 (JQ466_24065)	5180664..5181440	-	777	WP_003112898.1	ABC transporter permease	-
JQ466_RS24095 (JQ466_24070)	5181437..5182444	-	1008	WP_003112897.1	ABC transporter substrate-binding protein	-
JQ466_RS24100 (JQ466_24075)	5182485..5183336	-	852	WP_003130104.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30403.60 Da
• Isoelectric Point: 6.5894

>T190197 WP_003112901.1 NZ_CP069329:c5179344-5178475 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T190197 NZ_CP091143:c5847762-5847481 [Pseudomonas avellanae]
ATGCTGGTTGAGTGGCGGCCGGCAGCACGAATTAACCTGCAGCAAATACCTCTCTACATTGCAGACAGAAACGCACAAGC
AGCCAGCGAGCTGGGAATGGCGATAGAAGTAGCCACCTCAGCTCTCCCGCAACACCCTTGCTTGTACCGCCAAGGGCGAG
TGCCTGGAACCCGGGAAATCGTTGTCCACCCCAATTATCTCGTTGTGTACCGAGTGACAGATCGGATCGAAGTTCTCGCA
GTGCTTCACGCAAGGCATGCCTACCCTACCGACGCCGGGTAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT190197 WP_003112902.1 NZ_CP069329:c5178482-5177649 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

>AT190197 NZ_CP091143:c5847943-5847752 [Pseudomonas avellanae]
ATGAGCGCTCGAACTTCTCCAATCGTGTCGGAGTTTAAAACTGAGGAACAGGCCGCCAGCTACGACAAATGGTTTCGTGC
CCAGGTGCAGGCTTCAATCAGTGATCCAGCGCCAAATATTCCACACGATCAGGTCATGGCCGAGATGCGTGAATTTCTAG
AGTCGAAGCAGACTCCGTCAGATGCTGGTTGA

Structures

Toxin

• AlphaFold DB: Q9HYA0

Antitoxin

• AlphaFold DB: Q9HYA1