Detailed information of TA system TA190192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142956..143461
• Replicon: chromosome
• Accession: NZ_CP069329
• Organism: Pseudomonas aeruginosa strain R10

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: JQ466_RS00660
• Protein ID: WP_003083773.1
• Coordinates: 142956..143237 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: JQ466_RS00665
• Protein ID: WP_003083775.1
• Coordinates: 143234..143461 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ466_RS00635 (JQ466_00635)	138207..139556	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
JQ466_RS00640 (JQ466_00640)	139605..140291	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
JQ466_RS00645 (JQ466_00645)	140392..141126	+	735	WP_003117208.1	GntR family transcriptional regulator	-
JQ466_RS00650 (JQ466_00650)	141306..141716	+	411	WP_003101225.1	aegerolysin family protein	-
JQ466_RS00655 (JQ466_00655)	141748..142656	-	909	WP_010793581.1	LysR family transcriptional regulator	-
JQ466_RS00660 (JQ466_00660)	142956..143237	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
JQ466_RS00665 (JQ466_00665)	143234..143461	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
JQ466_RS00670 (JQ466_00670)	143637..144257	-	621	WP_003101226.1	hypothetical protein	-
JQ466_RS00675 (JQ466_00675)	144358..144858	+	501	WP_003101228.1	LEA type 2 family protein	-
JQ466_RS00680 (JQ466_00680)	144931..145272	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
JQ466_RS00685 (JQ466_00685)	145354..146781	-	1428	WP_003083784.1	GABA permease	-
JQ466_RS00690 (JQ466_00690)	146950..148443	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T190192 WP_003083773.1 NZ_CP069329:c143237-142956 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T190192 NZ_CP091143:2339988-2340272 [Pseudomonas avellanae]
CTGCAGGTTGAATGGCTAAAAACAGCATTAAAAAACCTGGATGATAAAGCCGCCTACATCTCGCTAGAAAATCCGGCTGC
TGCGGTTGTTTTCGTAGAAGCAATACAAATAAGCGTAAAGCAGCTCGCAAGCTTTCCGGCCCTAGGCCGAGAGGGACGAA
TTGCTGGCTCCAGAGAATGGCCTTTGCCAGACTGGCCTTACCTGATTCCATACCGCATCCGTAACGGCCGCTTACAGGTT
CTGCGGATTTTCCACATGAGAAGGCAGCCGCCGTTGGTGTGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT190192 WP_003083775.1 NZ_CP069329:c143461-143234 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT190192 NZ_CP091143:2339759-2339998 [Pseudomonas avellanae]
ATGTCCGTTATGTCTCTACGCCTGCCGGACGAGATGGCAGATACCCTTGCACACCTCGGCAAAGCGACCGGCCGCAGCAA
GTCGTTTTTGGCCCTGAACGCATTACGTGAATACTTGACTCGCGAAGCCTGGCAGATTGCCGAAATTCAGCGTGCAATTG
AAGAAGCAGACGCGGGCGAGTTTGCAAGTGAAGAAGATGTAAAGGCAGTGATGAATAAATGGGCGAACACTGCAGGTTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9