Detailed information of TA system TA190188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1837750..1839258
• Replicon: chromosome
• Accession: NZ_CP069328
• Organism: Pseudomonas aeruginosa strain R04

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JQ460_RS08575
• Protein ID: WP_124135728.1
• Coordinates: 1837750..1838337 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1C7C4U7
• Locus tag: JQ460_RS08580
• Protein ID: WP_003091607.1
• Coordinates: 1838404..1839258 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ460_RS08570 (JQ460_08560)	1834005..1837484	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
JQ460_RS08575 (JQ460_08565)	1837750..1838337	+	588	WP_124135728.1	GNAT family protein	Toxin
JQ460_RS08580 (JQ460_08570)	1838404..1839258	+	855	WP_003091607.1	AraC family transcriptional regulator	Antitoxin
JQ460_RS08585 (JQ460_08575)	1839355..1841520	+	2166	WP_010793245.1	TonB-dependent receptor family protein	-
JQ460_RS08590 (JQ460_08580)	1841695..1843569	+	1875	WP_010793244.1	MFS transporter	-
JQ460_RS08595 (JQ460_08585)	1843630..1843839	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21876.24 Da
• Isoelectric Point: 9.5192

>T190188 WP_124135728.1 NZ_CP069328:1837750-1838337 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGMALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Nucleotide

• Length: 588 bp

>T190188 NZ_CP091139:c1986311-1985919 [Microbacterium sp. KUDC0405]
GTGCTGGTCGACTCGTCCGCCTGGATCGAGTATCTGCGCGCGACAGGTTCGCCCGCGGATGCTGCCGTCGAACGGCTGAT
CCGCGAACAGGCTCCGCTGAAGACCTGTGAGCCGGTGATGATGGAACTGCTCGCCGGCGCGCGCTCGGACACCCACACAC
GCCAGTTGGAGCGACTGCTCGCGCGCGCGACCCTGCTGCCGACCCAGCCGACGGATTGGGTCGACGCCGCGCGCATCTAT
CGCACGGGACGTCGCGAGGGGGTGACGGTCCGCAGACTCGTCGACTGCCTCATCGCCGCCATCGCCCTGCGCAACGACGA
ATCGATCCTGCACCACGACGTCGATTTCGACGCCATCGCTCGCGTGACCTCGCTGACCGTCGCGCGCGACTGA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31895.20 Da
• Isoelectric Point: 7.5295

>AT190188 WP_003091607.1 NZ_CP069328:1838404-1839258 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Nucleotide

• Length: 855 bp

>AT190188 NZ_CP091139:c1986516-1986313 [Microbacterium sp. KUDC0405]
ATGACACGCACCAACATCGACCTGGACGACTCTGCCGTGGAGTCCGTGATGCGTCGGTTCGCGTTCTCGTCCAAGCGGGA
TGCCGTCAACTATGCGCTGCGCGCCCTCGCCGCCGATCCGCTGGACGTCGACAAGGCGCTGGCCTTGCGGGGGTCGGGGT
GGGAAGGCGATCTCGACGCGCTCCGCGAGAGCCGGGCATCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7C4U7