Detailed information of TA system TA190178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4386642..4387900
• Replicon: chromosome
• Accession: NZ_CP069326
• Organism: Pseudomonas aeruginosa strain R11

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: JQ467_RS20385
• Protein ID: WP_003112528.1
• Coordinates: 4386642..4387397 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JQ467_RS20390
• Protein ID: WP_003086329.1
• Coordinates: 4387532..4387900 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ467_RS20375 (JQ467_20355)	4381815..4384358	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
JQ467_RS20380 (JQ467_20360)	4384513..4385874	-	1362	WP_010895536.1	DNA recombination protein RmuC	-
JQ467_RS20385 (JQ467_20365)	4386642..4387397	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
JQ467_RS20390 (JQ467_20370)	4387532..4387900	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JQ467_RS20395 (JQ467_20375)	4387973..4389259	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
JQ467_RS20400 (JQ467_20380)	4389315..4390808	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
JQ467_RS20405 (JQ467_20385)	4390983..4391459	+	477	WP_003112531.1	hypothetical protein	-
JQ467_RS20410 (JQ467_20390)	4391462..4391737	-	276	WP_010793902.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T190178 WP_003112528.1 NZ_CP069326:c4387397-4386642 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T190178 NZ_CP091127:c9687-9271 [Serratia marcescens]
GTGAACAAGACCTATATGCTCGACACCTGTAGCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT190178 WP_003086329.1 NZ_CP069326:c4387900-4387532 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT190178 NZ_CP091127:c9914-9684 [Serratia marcescens]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7