Detailed information of TA system TA190177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3407429..3408650
• Replicon: chromosome
• Accession: NZ_CP069326
• Organism: Pseudomonas aeruginosa strain R11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: JQ467_RS15745
• Protein ID: WP_003102740.1
• Coordinates: 3408072..3408650 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQ467_RS15740
• Protein ID: WP_003088112.1
• Coordinates: 3407429..3407983 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ467_RS15715 (JQ467_15715)	3402997..3403548	+	552	WP_004343115.1	XRE family transcriptional regulator	-
JQ467_RS15720 (JQ467_15720)	3403545..3403943	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
JQ467_RS15725 (JQ467_15725)	3403956..3404279	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
JQ467_RS15730 (JQ467_15730)	3404610..3405071	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
JQ467_RS15735 (JQ467_15735)	3405076..3407271	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JQ467_RS15740 (JQ467_15740)	3407429..3407983	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
JQ467_RS15745 (JQ467_15745)	3408072..3408650	+	579	WP_003102740.1	HD domain-containing protein	Toxin
JQ467_RS15750 (JQ467_15750)	3408759..3409946	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JQ467_RS15755 (JQ467_15755)	3409936..3412107	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
JQ467_RS15760 (JQ467_15760)	3412097..3413374	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T190177 WP_003102740.1 NZ_CP069326:3408072-3408650 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T190177 NZ_CP091126:154778-155065 [Serratia marcescens]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT190177 WP_003088112.1 NZ_CP069326:3407429-3407983 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT190177 NZ_CP091126:154539-154778 [Serratia marcescens]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07