Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3340916..3342137 | Replicon | chromosome |
Accession | NZ_CP069325 | ||
Organism | Pseudomonas aeruginosa strain R02 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C7CS07 |
Locus tag | JQ458_RS15640 | Protein ID | WP_003102740.1 |
Coordinates | 3340916..3341494 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | JQ458_RS15645 | Protein ID | WP_003088112.1 |
Coordinates | 3341583..3342137 (-) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JQ458_RS15625 (JQ458_15590) | 3336192..3337469 | + | 1278 | WP_003102743.1 | TolC family protein | - |
JQ458_RS15630 (JQ458_15595) | 3337459..3339630 | + | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
JQ458_RS15635 (JQ458_15600) | 3339620..3340807 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
JQ458_RS15640 (JQ458_15605) | 3340916..3341494 | - | 579 | WP_003102740.1 | HD domain-containing protein | Toxin |
JQ458_RS15645 (JQ458_15610) | 3341583..3342137 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
JQ458_RS15650 (JQ458_15615) | 3342295..3344490 | - | 2196 | WP_010794059.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
JQ458_RS15655 (JQ458_15620) | 3344495..3344956 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
JQ458_RS15660 (JQ458_15625) | 3345287..3345610 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
JQ458_RS15665 (JQ458_15630) | 3345623..3346021 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
JQ458_RS15670 (JQ458_15635) | 3346018..3346569 | - | 552 | WP_004343115.1 | XRE family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21869.70 Da Isoelectric Point: 5.3655
>T190171 WP_003102740.1 NZ_CP069325:c3341494-3340916 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
>T190171 NZ_CP091125:c2798541-2798143 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT190171 WP_003088112.1 NZ_CP069325:c3342137-3341583 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
>AT190171 NZ_CP091125:c2798774-2798541 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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