190171

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 3340916..3342137 Replicon chromosome
Accession NZ_CP069325
Organism Pseudomonas aeruginosa strain R02

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag JQ458_RS15640 Protein ID WP_003102740.1
Coordinates 3340916..3341494 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQ458_RS15645 Protein ID WP_003088112.1
Coordinates 3341583..3342137 (-) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ458_RS15625 (JQ458_15590) 3336192..3337469 + 1278 WP_003102743.1 TolC family protein -
JQ458_RS15630 (JQ458_15595) 3337459..3339630 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
JQ458_RS15635 (JQ458_15600) 3339620..3340807 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
JQ458_RS15640 (JQ458_15605) 3340916..3341494 - 579 WP_003102740.1 HD domain-containing protein Toxin
JQ458_RS15645 (JQ458_15610) 3341583..3342137 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
JQ458_RS15650 (JQ458_15615) 3342295..3344490 - 2196 WP_010794059.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
JQ458_RS15655 (JQ458_15620) 3344495..3344956 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
JQ458_RS15660 (JQ458_15625) 3345287..3345610 + 324 WP_003102734.1 multidrug efflux SMR transporter -
JQ458_RS15665 (JQ458_15630) 3345623..3346021 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
JQ458_RS15670 (JQ458_15635) 3346018..3346569 - 552 WP_004343115.1 XRE family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-170)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T190171 WP_003102740.1 NZ_CP069325:c3341494-3340916 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T190171 NZ_CP091125:c2798541-2798143 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT190171 WP_003088112.1 NZ_CP069325:c3342137-3341583 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT190171 NZ_CP091125:c2798774-2798541 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07


Antitoxin

Source ID Structure

References