Detailed information of TA system TA190170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2361677..2362935
• Replicon: chromosome
• Accession: NZ_CP069325
• Organism: Pseudomonas aeruginosa strain R02

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: JQ458_RS10990
• Protein ID: WP_003112528.1
• Coordinates: 2362180..2362935 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JQ458_RS10985
• Protein ID: WP_003086329.1
• Coordinates: 2361677..2362045 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ458_RS10965 (JQ458_10950)	2357851..2358126	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
JQ458_RS10970 (JQ458_10955)	2358129..2358605	-	477	WP_003112531.1	hypothetical protein	-
JQ458_RS10975 (JQ458_10960)	2358780..2360262	+	1483	Protein_2154	aldehyde dehydrogenase family protein	-
JQ458_RS10980 (JQ458_10965)	2360318..2361604	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
JQ458_RS10985 (JQ458_10970)	2361677..2362045	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JQ458_RS10990 (JQ458_10975)	2362180..2362935	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
JQ458_RS10995 (JQ458_10980)	2363703..2365064	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
JQ458_RS11000 (JQ458_10985)	2365219..2367762	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T190170 WP_003112528.1 NZ_CP069325:2362180-2362935 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T190170 NZ_CP091125:1675025-1675121 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT190170 WP_003086329.1 NZ_CP069325:2361677-2362045 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT190170 NZ_CP091125:c1675121-1674981 [Serratia marcescens]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7