190168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142971..143476 Replicon chromosome
Accession NZ_CP069325
Organism Pseudomonas aeruginosa strain R02

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag JQ458_RS00660 Protein ID WP_003083773.1
Coordinates 142971..143252 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag JQ458_RS00665 Protein ID WP_003083775.1
Coordinates 143249..143476 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ458_RS00635 (JQ458_00635) 138222..139571 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
JQ458_RS00640 (JQ458_00640) 139620..140306 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
JQ458_RS00645 (JQ458_00645) 140407..141141 + 735 WP_003117208.1 GntR family transcriptional regulator -
JQ458_RS00650 (JQ458_00650) 141321..141731 + 411 WP_003101225.1 aegerolysin family protein -
JQ458_RS00655 (JQ458_00655) 141763..142671 - 909 WP_010793581.1 LysR family transcriptional regulator -
JQ458_RS00660 (JQ458_00660) 142971..143252 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
JQ458_RS00665 (JQ458_00665) 143249..143476 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
JQ458_RS00670 (JQ458_00670) 143652..144272 - 621 WP_003101226.1 hypothetical protein -
JQ458_RS00675 (JQ458_00675) 144373..144873 + 501 WP_003101228.1 LEA type 2 family protein -
JQ458_RS00680 (JQ458_00680) 144946..145287 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
JQ458_RS00685 (JQ458_00685) 145369..146796 - 1428 WP_003083784.1 GABA permease -
JQ458_RS00690 (JQ458_00690) 146965..148458 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T190168 WP_003083773.1 NZ_CP069325:c143252-142971 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T190168 NZ_CP091125:c1016255-1015950 [Serratia marcescens]
ATGCCCGCGTTTCGCCTCACCCCGCAGGCCCAACAAGATCTGCTGGCTATTCGTCATTTCACCATCGAGCACTGGGGCCA
AGCGCAATCTCGCCGCTATCTTGAGCAGTTGAGAGAGGTCATGCATCATTTGGCAGATATGCCGGAAGCGGGTAAAGCTC
ACTTCCACGATCTGGGCGAAGAGATACGCAGTTTTCCTTACGCCAGCCATAGGATCTACTACCGCAACCGCCCTGCCGGC
ATCACCGTTCTCGCCATTCTGCATCAGGCGATGGTGCCTCACCGGCATCTGGAACAACGGCTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT190168 WP_003083775.1 NZ_CP069325:c143476-143249 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT190168 NZ_CP091125:c1016517-1016257 [Serratia marcescens]
ATGTACGCACTCACCGCGAACGAGGCCAAAACCCAATTCGGCGATTTGCTGCTCAAGGCGCAGCGTGAACCGGTGCAAAT
CAATCGCAACGGCAAACCGGTCGCCGTCGTCATGTCTGTAGAAGATTACCAGGCGCTGGAAGATCTCAAATTAAGCGCAC
TGCAGCAAAAAATCGCGCAGGCTACCGCCGAGGAAGACGCCGGTAAGGCGGTAGACGGCGATGCCTTCTTCAACCGTCTA
CTCACCGATGAAACAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References