Detailed information of TA system TA190159

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3406976..3408197
• Replicon: chromosome
• Accession: NZ_CP069323
• Organism: Pseudomonas aeruginosa strain R06

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: JQ462_RS15740
• Protein ID: WP_003102740.1
• Coordinates: 3407619..3408197 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQ462_RS15735
• Protein ID: WP_003088112.1
• Coordinates: 3406976..3407530 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ462_RS15710 (JQ462_15705)	3402544..3403095	+	552	WP_004343115.1	XRE family transcriptional regulator	-
JQ462_RS15715 (JQ462_15710)	3403092..3403490	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
JQ462_RS15720 (JQ462_15715)	3403503..3403826	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
JQ462_RS15725 (JQ462_15720)	3404157..3404618	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
JQ462_RS15730 (JQ462_15725)	3404623..3406818	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JQ462_RS15735 (JQ462_15730)	3406976..3407530	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
JQ462_RS15740 (JQ462_15735)	3407619..3408197	+	579	WP_003102740.1	HD domain-containing protein	Toxin
JQ462_RS15745 (JQ462_15740)	3408306..3409493	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JQ462_RS15750 (JQ462_15745)	3409483..3411654	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
JQ462_RS15755 (JQ462_15750)	3411644..3412921	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T190159 WP_003102740.1 NZ_CP069323:3407619-3408197 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T190159 NZ_CP091123:c3166999-3166601 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGTATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT190159 WP_003088112.1 NZ_CP069323:3406976-3407530 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT190159 NZ_CP091123:c3167232-3166999 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07