Detailed information of TA system TA190156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142956..143461
• Replicon: chromosome
• Accession: NZ_CP069323
• Organism: Pseudomonas aeruginosa strain R06

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: JQ462_RS00660
• Protein ID: WP_003083773.1
• Coordinates: 142956..143237 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: JQ462_RS00665
• Protein ID: WP_003083775.1
• Coordinates: 143234..143461 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ462_RS00635 (JQ462_00635)	138207..139556	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
JQ462_RS00640 (JQ462_00640)	139605..140291	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
JQ462_RS00645 (JQ462_00645)	140392..141126	+	735	WP_003117208.1	GntR family transcriptional regulator	-
JQ462_RS00650 (JQ462_00650)	141306..141716	+	411	WP_003101225.1	aegerolysin family protein	-
JQ462_RS00655 (JQ462_00655)	141748..142656	-	909	WP_010793581.1	LysR family transcriptional regulator	-
JQ462_RS00660 (JQ462_00660)	142956..143237	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
JQ462_RS00665 (JQ462_00665)	143234..143461	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
JQ462_RS00670 (JQ462_00670)	143637..144257	-	621	WP_003101226.1	hypothetical protein	-
JQ462_RS00675 (JQ462_00675)	144358..144858	+	501	WP_003101228.1	LEA type 2 family protein	-
JQ462_RS00680 (JQ462_00680)	144931..145272	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
JQ462_RS00685 (JQ462_00685)	145354..146781	-	1428	WP_003083784.1	GABA permease	-
JQ462_RS00690 (JQ462_00690)	146950..148443	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T190156 WP_003083773.1 NZ_CP069323:c143237-142956 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T190156 NZ_CP091123:c1014383-1014180 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT190156 WP_003083775.1 NZ_CP069323:c143461-143234 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT190156 NZ_CP091123:c1014802-1014434 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9