Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4817946..4818559 | Replicon | chromosome |
Accession | NZ_CP069319 | ||
Organism | Kosakonia cowanii strain Pa82 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | JMT66_RS22800 | Protein ID | WP_232045126.1 |
Coordinates | 4817946..4818323 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | JMT66_RS22805 | Protein ID | WP_042712315.1 |
Coordinates | 4818317..4818559 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMT66_RS22785 (JMT66_22725) | 4815447..4816349 | + | 903 | WP_023479333.1 | formate dehydrogenase subunit beta | - |
JMT66_RS22790 (JMT66_22730) | 4816346..4816984 | + | 639 | WP_023479367.1 | formate dehydrogenase cytochrome b556 subunit | - |
JMT66_RS22795 (JMT66_22735) | 4816981..4817910 | + | 930 | WP_023479362.1 | formate dehydrogenase accessory protein FdhE | - |
JMT66_RS22800 (JMT66_22740) | 4817946..4818323 | - | 378 | WP_232045126.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JMT66_RS22805 (JMT66_22745) | 4818317..4818559 | - | 243 | WP_042712315.1 | CopG family transcriptional regulator | Antitoxin |
JMT66_RS22810 (JMT66_22750) | 4818761..4819672 | + | 912 | WP_200135227.1 | alpha/beta hydrolase | - |
JMT66_RS22815 (JMT66_22755) | 4819726..4820667 | - | 942 | WP_023479318.1 | fatty acid biosynthesis protein FabY | - |
JMT66_RS22820 (JMT66_22760) | 4820712..4821146 | - | 435 | WP_023479361.1 | D-aminoacyl-tRNA deacylase | - |
JMT66_RS22825 (JMT66_22765) | 4821143..4822015 | - | 873 | WP_076768859.1 | virulence factor BrkB family protein | - |
JMT66_RS22830 (JMT66_22770) | 4822012..4822608 | - | 597 | WP_054804144.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14015.14 Da Isoelectric Point: 5.1471
>T190153 WP_232045126.1 NZ_CP069319:c4818323-4817946 [Kosakonia cowanii]
MVTMSNLALFDTNILIDLFNGREEAANTFEDYNGRIAISLISWIEVLVGAKKVGQENATRAFLDSLEVIEISHPIAERSI
ELRQAYRMKLPDAIILATAQIHSRCLVTRNIKDFASVTGVFTPYQ
MVTMSNLALFDTNILIDLFNGREEAANTFEDYNGRIAISLISWIEVLVGAKKVGQENATRAFLDSLEVIEISHPIAERSI
ELRQAYRMKLPDAIILATAQIHSRCLVTRNIKDFASVTGVFTPYQ
Download Length: 378 bp
>T190153 NZ_CP091123:56154-56429 [Serratia marcescens]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9241.47 Da Isoelectric Point: 4.5230
>AT190153 WP_042712315.1 NZ_CP069319:c4818559-4818317 [Kosakonia cowanii]
MDVLSGVIMGRILLDLSDDVIRRLDSLKQQRNLPRAELLREAVEQYLEKQNTTSARNALGLWGGEGEDGLEFERKLREEW
MDVLSGVIMGRILLDLSDDVIRRLDSLKQQRNLPRAELLREAVEQYLEKQNTTSARNALGLWGGEGEDGLEFERKLREEW
Download Length: 243 bp
>AT190153 NZ_CP091123:55894-56154 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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