Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4817946..4818559 Replicon chromosome
Accession NZ_CP069319
Organism Kosakonia cowanii strain Pa82

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMT66_RS22800 Protein ID WP_232045126.1
Coordinates 4817946..4818323 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMT66_RS22805 Protein ID WP_042712315.1
Coordinates 4818317..4818559 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMT66_RS22785 (JMT66_22725) 4815447..4816349 + 903 WP_023479333.1 formate dehydrogenase subunit beta -
JMT66_RS22790 (JMT66_22730) 4816346..4816984 + 639 WP_023479367.1 formate dehydrogenase cytochrome b556 subunit -
JMT66_RS22795 (JMT66_22735) 4816981..4817910 + 930 WP_023479362.1 formate dehydrogenase accessory protein FdhE -
JMT66_RS22800 (JMT66_22740) 4817946..4818323 - 378 WP_232045126.1 type II toxin-antitoxin system VapC family toxin Toxin
JMT66_RS22805 (JMT66_22745) 4818317..4818559 - 243 WP_042712315.1 CopG family transcriptional regulator Antitoxin
JMT66_RS22810 (JMT66_22750) 4818761..4819672 + 912 WP_200135227.1 alpha/beta hydrolase -
JMT66_RS22815 (JMT66_22755) 4819726..4820667 - 942 WP_023479318.1 fatty acid biosynthesis protein FabY -
JMT66_RS22820 (JMT66_22760) 4820712..4821146 - 435 WP_023479361.1 D-aminoacyl-tRNA deacylase -
JMT66_RS22825 (JMT66_22765) 4821143..4822015 - 873 WP_076768859.1 virulence factor BrkB family protein -
JMT66_RS22830 (JMT66_22770) 4822012..4822608 - 597 WP_054804144.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14015.14 Da        Isoelectric Point: 5.1471

>T190153 WP_232045126.1 NZ_CP069319:c4818323-4817946 [Kosakonia cowanii]
MVTMSNLALFDTNILIDLFNGREEAANTFEDYNGRIAISLISWIEVLVGAKKVGQENATRAFLDSLEVIEISHPIAERSI
ELRQAYRMKLPDAIILATAQIHSRCLVTRNIKDFASVTGVFTPYQ

Download         Length: 378 bp

>T190153 NZ_CP091123:56154-56429 [Serratia marcescens]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9241.47 Da        Isoelectric Point: 4.5230

>AT190153 WP_042712315.1 NZ_CP069319:c4818559-4818317 [Kosakonia cowanii]
MDVLSGVIMGRILLDLSDDVIRRLDSLKQQRNLPRAELLREAVEQYLEKQNTTSARNALGLWGGEGEDGLEFERKLREEW

Download         Length: 243 bp

>AT190153 NZ_CP091123:55894-56154 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References