Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4585980..4586566 Replicon chromosome
Accession NZ_CP069319
Organism Kosakonia cowanii strain Pa82

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JMT66_RS21710 Protein ID WP_128483861.1
Coordinates 4585980..4586270 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag JMT66_RS21715 Protein ID WP_042712602.1
Coordinates 4586288..4586566 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMT66_RS21690 (JMT66_21630) 4581770..4583356 + 1587 WP_200580339.1 RNA repair transcriptional activator RtcR -
JMT66_RS21695 (JMT66_21635) 4583506..4584447 + 942 WP_200134476.1 ketopantoate/pantoate/pantothenate transporter PanS -
JMT66_RS21700 (JMT66_21640) 4584597..4584869 + 273 WP_042712605.1 DUF3811 domain-containing protein -
JMT66_RS21705 (JMT66_21645) 4584870..4585739 - 870 WP_094419107.1 23S rRNA pseudouridine(2604) synthase RluF -
JMT66_RS21710 (JMT66_21650) 4585980..4586270 + 291 WP_128483861.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMT66_RS21715 (JMT66_21655) 4586288..4586566 + 279 WP_042712602.1 putative addiction module antidote protein Antitoxin
JMT66_RS21720 (JMT66_21660) 4586595..4588226 - 1632 WP_042712600.1 Na/Pi cotransporter family protein -
JMT66_RS21725 (JMT66_21665) 4588398..4588874 - 477 WP_232045116.1 hypothetical protein -
JMT66_RS21730 (JMT66_21670) 4588849..4589625 - 777 WP_200134474.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(28-82)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10719.56 Da        Isoelectric Point: 9.9480

>T190152 WP_128483861.1 NZ_CP069319:4585980-4586270 [Kosakonia cowanii]
MKEIVQTDAFKLWESSLRDAKLRAIISARLFRLANGLTGDVKPVGEGISELRIHYGAGYRIYFQLRGNTVVVLLCGGDKS
TQPKDIIYAKYLAKCV

Download         Length: 291 bp

>T190152 NZ_CP091123:c14659-14279 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATAGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9818.36 Da        Isoelectric Point: 6.2978

>AT190152 WP_042712602.1 NZ_CP069319:4586288-4586566 [Kosakonia cowanii]
MNKLTPYDPAAALVNDEAIALFMADALETGDAAYIARALGVIARAKGMSDIAAETGLSREQLYRSFSEKGNPTLKTTLSV
MKALGIELTVKR

Download         Length: 279 bp

>AT190152 NZ_CP091123:c14880-14659 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References