Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PumAB/COG3657-dnstrm_HI1420 |
Location | 4585980..4586566 | Replicon | chromosome |
Accession | NZ_CP069319 | ||
Organism | Kosakonia cowanii strain Pa82 |
Toxin (Protein)
Gene name | PumA | Uniprot ID | - |
Locus tag | JMT66_RS21710 | Protein ID | WP_128483861.1 |
Coordinates | 4585980..4586270 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | - |
Locus tag | JMT66_RS21715 | Protein ID | WP_042712602.1 |
Coordinates | 4586288..4586566 (+) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMT66_RS21690 (JMT66_21630) | 4581770..4583356 | + | 1587 | WP_200580339.1 | RNA repair transcriptional activator RtcR | - |
JMT66_RS21695 (JMT66_21635) | 4583506..4584447 | + | 942 | WP_200134476.1 | ketopantoate/pantoate/pantothenate transporter PanS | - |
JMT66_RS21700 (JMT66_21640) | 4584597..4584869 | + | 273 | WP_042712605.1 | DUF3811 domain-containing protein | - |
JMT66_RS21705 (JMT66_21645) | 4584870..4585739 | - | 870 | WP_094419107.1 | 23S rRNA pseudouridine(2604) synthase RluF | - |
JMT66_RS21710 (JMT66_21650) | 4585980..4586270 | + | 291 | WP_128483861.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JMT66_RS21715 (JMT66_21655) | 4586288..4586566 | + | 279 | WP_042712602.1 | putative addiction module antidote protein | Antitoxin |
JMT66_RS21720 (JMT66_21660) | 4586595..4588226 | - | 1632 | WP_042712600.1 | Na/Pi cotransporter family protein | - |
JMT66_RS21725 (JMT66_21665) | 4588398..4588874 | - | 477 | WP_232045116.1 | hypothetical protein | - |
JMT66_RS21730 (JMT66_21670) | 4588849..4589625 | - | 777 | WP_200134474.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 10719.56 Da Isoelectric Point: 9.9480
>T190152 WP_128483861.1 NZ_CP069319:4585980-4586270 [Kosakonia cowanii]
MKEIVQTDAFKLWESSLRDAKLRAIISARLFRLANGLTGDVKPVGEGISELRIHYGAGYRIYFQLRGNTVVVLLCGGDKS
TQPKDIIYAKYLAKCV
MKEIVQTDAFKLWESSLRDAKLRAIISARLFRLANGLTGDVKPVGEGISELRIHYGAGYRIYFQLRGNTVVVLLCGGDKS
TQPKDIIYAKYLAKCV
Download Length: 291 bp
>T190152 NZ_CP091123:c14659-14279 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATAGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATAGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
Antitoxin
Download Length: 93 a.a. Molecular weight: 9818.36 Da Isoelectric Point: 6.2978
>AT190152 WP_042712602.1 NZ_CP069319:4586288-4586566 [Kosakonia cowanii]
MNKLTPYDPAAALVNDEAIALFMADALETGDAAYIARALGVIARAKGMSDIAAETGLSREQLYRSFSEKGNPTLKTTLSV
MKALGIELTVKR
MNKLTPYDPAAALVNDEAIALFMADALETGDAAYIARALGVIARAKGMSDIAAETGLSREQLYRSFSEKGNPTLKTTLSV
MKALGIELTVKR
Download Length: 279 bp
>AT190152 NZ_CP091123:c14880-14659 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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