Detailed information of TA system TA190151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4339615..4340131
• Replicon: chromosome
• Accession: NZ_CP069319
• Organism: Kosakonia cowanii strain Pa82

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JMT66_RS20615
• Protein ID: WP_094419229.1
• Coordinates: 4339615..4339899 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JMT66_RS20620
• Protein ID: WP_042714051.1
• Coordinates: 4339889..4340131 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMT66_RS20600 (JMT66_20540)	4335473..4336417	+	945	WP_200581309.1	trehalose operon repressor TreR	-
JMT66_RS20605 (JMT66_20545)	4336765..4338900	+	2136	WP_200581308.1	anaerobic ribonucleoside-triphosphate reductase	-
JMT66_RS20610 (JMT66_20550)	4339145..4339609	+	465	WP_200581307.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JMT66_RS20615 (JMT66_20555)	4339615..4339899	-	285	WP_094419229.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMT66_RS20620 (JMT66_20560)	4339889..4340131	-	243	WP_042714051.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JMT66_RS20625 (JMT66_20565)	4340210..4342120	-	1911	WP_200581306.1	PRD domain-containing protein	-
JMT66_RS20630 (JMT66_20570)	4342204..4342941	-	738	WP_200581305.1	KDGP aldolase family protein	-
JMT66_RS20635 (JMT66_20575)	4342938..4344056	-	1119	WP_094419227.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.90 Da
• Isoelectric Point: 10.5826

>T190151 WP_094419229.1 NZ_CP069319:c4339899-4339615 [Kosakonia cowanii]
MIYELAFDPRALKEWKKLGVTVQAQFKKKLAEVLVQPRVEKARLHGLPDCYKIKLRASGYRLIYQVRDNVVTVFVVAIGK
REKEAAYHSATHRL

Nucleotide

• Length: 285 bp

>T190151 NZ_CP091122:4682704-4683054 [Serratia marcescens]
ATGGTGAAGCGCCCCGTTTTTCAGCGCGGAGATCTTATCCGGGTCAGCCTGAATCCCGTGGTTGGCCGTGAGCAGCAAGG
CGACTTTCGTCCGGCACTGGTGCTCTCTCCCCGCGAGTTTAATGCGTTGGGCATGGTGCTGGTCGCCCCTATTTCGCAAG
GGGCTAATTTTGCCCGTACAGCGGGTTTCACCGTCAGCCTGAGCGGGAGCGGCACCGCAACGCAGGGCGTCATCTTGATC
AACCAGGTTCGCATGATGGATCTGGCCGGGCGCAGCGCGCAATTCATTGAACGTGCCCCTGGCGAAGTCATCACCGACGC
GCTGGCGCGGCTTCAGGCAATCATCGACTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9133.62 Da
• Isoelectric Point: 4.8537

>AT190151 WP_042714051.1 NZ_CP069319:c4340131-4339889 [Kosakonia cowanii]
MATLNVRLDDKLKEEAWKVLEKLDITPTEAVRLLFQYVAENGRMPVKTVTVSEDEAALLEVVRERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT190151 NZ_CP091122:4682462-4682710 [Serratia marcescens]
ATGAAAGTCTTTATCAAAAAATGGGGCAACAGCGCGGGAATGCTGGTGCCCTCAGCGCTAATGAACGAGCTGGAACTACA
GGTAGGTCAGGAAATGGACATGCAGGTCATCGATGGAGCGTTGATCATTAAACCGGTTAAGAAACGCTATTCACTGCAGC
AATTGCTCGATGGCTGCGACGGTGAAGCGCCGGCCGCCGCAGACGACAACTGGGAACACATGCCGCCGGCGGGGAAAGAA
GTATGGTGA