Detailed information of TA system TA190150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 4205280..4205844
• Replicon: chromosome
• Accession: NZ_CP069319
• Organism: Kosakonia cowanii strain Pa82

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JMT66_RS19980
• Protein ID: WP_200579836.1
• Coordinates: 4205280..4205585 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JMT66_RS19985
• Protein ID: WP_042714565.1
• Coordinates: 4205572..4205844 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMT66_RS19955 (JMT66_19910)	4200378..4201334	+	957	WP_200579840.1	GTPase	-
JMT66_RS19960 (JMT66_19915)	4201507..4202877	-	1371	WP_200579839.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
JMT66_RS19965 (JMT66_19920)	4203213..4203734	+	522	WP_200579838.1	VOC family protein	-
JMT66_RS19970 (JMT66_19925)	4203841..4204605	+	765	WP_200579919.1	AraC family transcriptional regulator	-
JMT66_RS19975 (JMT66_19930)	4204652..4205275	+	624	WP_200579837.1	LysE family translocator	-
JMT66_RS19980 (JMT66_19935)	4205280..4205585	-	306	WP_200579836.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JMT66_RS19985 (JMT66_19940)	4205572..4205844	-	273	WP_042714565.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JMT66_RS19990 (JMT66_19945)	4205930..4207210	+	1281	WP_200579835.1	DUF445 domain-containing protein	-
JMT66_RS19995 (JMT66_19950)	4207306..4208370	-	1065	WP_042714560.1	DUF2955 domain-containing protein	-
JMT66_RS20000 (JMT66_19955)	4208360..4209427	-	1068	WP_042714559.1	HlyD family secretion protein	-
JMT66_RS20005 (JMT66_19960)	4209432..4209899	-	468	WP_042714558.1	MarR family transcriptional regulator	-
JMT66_RS20010 (JMT66_19965)	4209999..4210169	-	171	Protein_3917	glutathione transferase	-
JMT66_RS20015	4210309..4210512	-	204	WP_232045514.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-85)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11589.23 Da
• Isoelectric Point: 9.3769

>T190150 WP_200579836.1 NZ_CP069319:c4205585-4205280 [Kosakonia cowanii]
MGKSKRARLPFRSDYTKTFVKAWERYNKAGRRDMHETAAIMSMVLSGNPLPAQYNDHALTGNMQGFRELHIGGDYLLVYR
LDGEKHLVVFTDLGTHAELFE

Nucleotide

• Length: 306 bp

>T190150 NZ_CP091122:4404275-4404565 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAGGCGCAGCCGTCTGATCCCCGGCGCGCT
TGAGCGACAGTTGGCCAGAAAACTCGATATGTTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGACCATTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCATCAAGATACCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10049.44 Da
• Isoelectric Point: 4.6683

>AT190150 WP_042714565.1 NZ_CP069319:c4205844-4205572 [Kosakonia cowanii]
MDSVIRSRIDSELKARAGLVLENCGLNWSTAIRLFAEQIVKNEGIPFEITAKPTARLRNAMVEAEEIAAQKQGRFESVEQ
LMDSLNDGKE

Nucleotide

• Length: 273 bp

>AT190150 NZ_CP091122:4404580-4404903 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGAGAAGTGCTGCAGGAAGAATATTTAACGCCGCTAGGCATCGG
CCAGGAGGAACTGGCAAAGGTATTGGGCGTCACCCGCGCCACCGTCAATCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAATCTGTTTGCCGATCTGTTCGAAACGACCGCTGACTTTTGGCTAAACCTGCAGGCGGCGCACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAGCGTGTGCGGTTGCGGCCGATCAAAGAAATACTGAGGCGCAATATCACTCATGC
ATGA