Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 664383..664902 Replicon chromosome
Accession NZ_CP069319
Organism Kosakonia cowanii strain Pa82

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag JMT66_RS03295 Protein ID WP_232045208.1
Coordinates 664383..664664 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag JMT66_RS03300 Protein ID WP_200579705.1
Coordinates 664654..664902 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMT66_RS03270 (JMT66_03255) 659811..660443 + 633 WP_023480789.1 ADP-ribose diphosphatase -
JMT66_RS03275 (JMT66_03260) 660440..660862 + 423 WP_023480711.1 DUF1249 family protein -
JMT66_RS03280 (JMT66_03265) 660887..661714 + 828 WP_076769222.1 3',5'-cyclic-AMP phosphodiesterase -
JMT66_RS03285 (JMT66_03270) 661714..662289 + 576 WP_200579706.1 esterase YqiA -
JMT66_RS03290 (JMT66_03275) 662329..664221 + 1893 WP_042717986.1 DNA topoisomerase IV subunit B -
JMT66_RS03295 (JMT66_03280) 664383..664664 - 282 WP_232045208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMT66_RS03300 (JMT66_03285) 664654..664902 - 249 WP_200579705.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMT66_RS03305 (JMT66_03290) 664953..665828 - 876 WP_200579704.1 AraC family transcriptional regulator -
JMT66_RS03310 (JMT66_03295) 665994..667820 + 1827 WP_200579703.1 DUF2264 domain-containing protein -
JMT66_RS03315 (JMT66_03300) 667878..669137 + 1260 WP_023480794.1 oligosaccharide MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 584857..676395 91538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10905.70 Da        Isoelectric Point: 10.6500

>T190139 WP_232045208.1 NZ_CP069319:c664664-664383 [Kosakonia cowanii]
MTYKLAFNVSALKEWKKLGSTVREQFKKKLQERLENPRVPAAQLNGRKDQYKIKLRGAGYRLVYKVEEEIITVTVIGVGK
RENDEIYTATRFR

Download         Length: 282 bp

>T190139 NZ_CP091121:c4169215-4168793 [Serratia ureilytica]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTCTCTCTGTTGACCCACGGCGTCCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGTA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGTGAACTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTACAGCCTATGGAGGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGTTGTATCCGCCGG
CGGGTGACGGCGAACAAGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.34 Da        Isoelectric Point: 3.9490

>AT190139 WP_200579705.1 NZ_CP069319:c664902-664654 [Kosakonia cowanii]
MPFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYARLMELLEDEELGRIADERADEPTIEVKLD
DL

Download         Length: 249 bp

>AT190139 NZ_CP091121:c4169462-4169196 [Serratia ureilytica]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTCATCCGTCTGCTCGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References