Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6491791..6493474 Replicon chromosome
Accession NZ_CP069318
Organism Delftia lacustris strain R54

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JQN63_RS29715 Protein ID WP_203400094.1
Coordinates 6492620..6493474 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A072T3J4
Locus tag JQN63_RS29710 Protein ID WP_016449819.1
Coordinates 6491791..6492597 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN63_RS29680 6487706..6487987 + 282 WP_071954164.1 hypothetical protein -
JQN63_RS29685 6488133..6489099 - 967 Protein_5850 transposase -
JQN63_RS29690 6489409..6489753 + 345 Protein_5851 type II toxin-antitoxin system RelE/ParE family toxin -
JQN63_RS29695 6489754..6490062 + 309 WP_016449816.1 XRE family transcriptional regulator -
JQN63_RS29700 6490075..6490836 - 762 WP_016449817.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
JQN63_RS29705 6490939..6491736 - 798 WP_016449818.1 aspartate dehydrogenase -
JQN63_RS29710 6491791..6492597 - 807 WP_016449819.1 IclR family transcriptional regulator Antitoxin
JQN63_RS29715 6492620..6493474 - 855 WP_203400094.1 alpha/beta fold hydrolase Toxin
JQN63_RS29720 6493639..6494169 - 531 WP_016449821.1 cupin domain-containing protein -
JQN63_RS29725 6494369..6495565 - 1197 WP_034363546.1 MFS transporter -
JQN63_RS29730 6495588..6496472 - 885 WP_203400095.1 NAD(P)-dependent oxidoreductase -
JQN63_RS29735 6496609..6497198 - 590 Protein_5860 TetR/AcrR family transcriptional regulator -
JQN63_RS29740 6497280..6497771 - 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29474.83 Da        Isoelectric Point: 7.3740

>T190136 WP_203400094.1 NZ_CP069318:c6493474-6492620 [Delftia lacustris]
MTPSVTACMEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWLDVALALAPRTRVLAWDAPGYGR
STPLAPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T190136 NZ_CP091121:2043249-2043345 [Serratia ureilytica]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29047.08 Da        Isoelectric Point: 5.3408

>AT190136 WP_016449819.1 NZ_CP069318:c6492597-6491791 [Delftia lacustris]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Download         Length: 807 bp

>AT190136 NZ_CP091121:c2043345-2043205 [Serratia ureilytica]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A072T3J4

References