Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2684184..2684893 Replicon chromosome
Accession NZ_CP069318
Organism Delftia lacustris strain R54

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQN63_RS12430 Protein ID WP_016453265.1
Coordinates 2684184..2684630 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQN63_RS12435 Protein ID WP_203400733.1
Coordinates 2684627..2684893 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN63_RS12410 2679782..2680996 + 1215 WP_203400729.1 ABC transporter permease -
JQN63_RS12415 2680998..2682143 + 1146 WP_203400730.1 ABC transporter permease -
JQN63_RS12420 2682207..2682836 - 630 WP_203400731.1 DUF4124 domain-containing protein -
JQN63_RS12425 2682915..2684120 - 1206 WP_203400732.1 MFS transporter -
JQN63_RS12430 2684184..2684630 - 447 WP_016453265.1 type II toxin-antitoxin system VapC family toxin Toxin
JQN63_RS12435 2684627..2684893 - 267 WP_203400733.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JQN63_RS12440 2684918..2685889 - 972 WP_203400734.1 LysR family transcriptional regulator -
JQN63_RS12445 2685966..2686850 + 885 WP_203400735.1 amidohydrolase family protein -
JQN63_RS12450 2686877..2687872 + 996 WP_016448238.1 tripartite tricarboxylate transporter substrate binding protein -
JQN63_RS12455 2687896..2689527 - 1632 WP_016448237.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15880.46 Da        Isoelectric Point: 8.1045

>T190133 WP_016453265.1 NZ_CP069318:c2684630-2684184 [Delftia lacustris]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEATGITLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Download         Length: 447 bp

>T190133 NZ_CP091121:62002-62277 [Serratia ureilytica]
ATGGAGTTAAAATGGACGAGTAAGGCGCTACCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCGGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10018.00 Da        Isoelectric Point: 4.3846

>AT190133 WP_203400733.1 NZ_CP069318:c2684893-2684627 [Delftia lacustris]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPATGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Download         Length: 267 bp

>AT190133 NZ_CP091121:61742-62002 [Serratia ureilytica]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCGTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References