Detailed information of TA system TA190132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1128926..1129635
• Replicon: chromosome
• Accession: NZ_CP069318
• Organism: Delftia lacustris strain R54

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A210VR27
• Locus tag: JQN63_RS05130
• Protein ID: WP_011805136.1
• Coordinates: 1129252..1129635 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: JQN63_RS05125
• Protein ID: WP_011805135.1
• Coordinates: 1128926..1129255 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN63_RS05110	1125195..1125389	-	195	Protein_1006	hypothetical protein	-
JQN63_RS05115	1125534..1128449	-	2916	WP_003049965.1	Tn3-like element IS1071 family transposase	-
JQN63_RS05120	1128590..1128913	+	324	Protein_1008	site-specific integrase	-
JQN63_RS05125	1128926..1129255	-	330	WP_011805135.1	helix-turn-helix domain-containing protein	Antitoxin
JQN63_RS05130	1129252..1129635	-	384	WP_011805136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JQN63_RS05135	1129712..1130305	+	594	WP_088167134.1	ABC transporter substrate-binding protein	-
JQN63_RS05140	1130442..1131922	+	1481	Protein_1012	aldehyde dehydrogenase	-
JQN63_RS05145	1131970..1133025	+	1056	WP_017404448.1	zinc-binding dehydrogenase	-
JQN63_RS05150	1133126..1133983	-	858	WP_103738775.1	carboxylating nicotinate-nucleotide diphosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1122763..1146940	24177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14062.15 Da
• Isoelectric Point: 10.0145

>T190132 WP_011805136.1 NZ_CP069318:c1129635-1129252 [Delftia lacustris]
MSTQPRKPLKWVGSAKRDLDGMPEDVQDVFGHAIDLAQAGGKHPDAKALSGFGSAAVLEVVEDFRSDTFRAVYTVKFAGW
VYVLHCFQKKSKSGIKTPKEDLDLIKARLKAAVQDFEAWQAKQGVKR

Nucleotide

• Length: 384 bp

>T190132 NZ_CP091121:c14522-14142 [Serratia ureilytica]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACCGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11929.73 Da
• Isoelectric Point: 10.5281

>AT190132 WP_011805135.1 NZ_CP069318:c1129255-1128926 [Delftia lacustris]
MSQNSHITIEEGSTNVYADLGYADAAEMQRKSQLAAEIARAIKARRLTQQGAAALLEIDQSKISRITRGQFRGVSEAKLL
ELVAKLGHDVKIVVGPVRRRAGKIELQFA

Nucleotide

• Length: 330 bp

>AT190132 NZ_CP091121:c14743-14522 [Serratia ureilytica]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATTCGTCAAGCAGTCTCCCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Toxin

• AlphaFold DB: A0A210VR27