Detailed information of TA system TA190129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2168662..2170349
• Replicon: chromosome
• Accession: NZ_CP069308
• Organism: Glaesserella parasuis strain EHP1804

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A084EEY9
• Locus tag: JQC68_RS10955
• Protein ID: WP_021113222.1
• Coordinates: 2169006..2170349 (-)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JQC68_RS10950
• Protein ID: WP_015940035.1
• Coordinates: 2168662..2169006 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQC68_RS10930	2164730..2165680	-	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-
JQC68_RS10935	2165708..2166553	-	846	WP_021113204.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
JQC68_RS10940	2166555..2167187	-	633	WP_021110345.1	lipoprotein insertase outer membrane protein LolB	-
JQC68_RS10945	2167308..2168633	-	1326	WP_203399093.1	ATP-dependent RNA helicase SrmB	-
JQC68_RS10950	2168662..2169006	-	345	WP_015940035.1	helix-turn-helix domain-containing protein	Antitoxin
JQC68_RS10955	2169006..2170349	-	1344	WP_021113222.1	type II toxin-antitoxin system HipA family toxin	Toxin
JQC68_RS10960	2170463..2170900	-	438	WP_035523310.1	ribosomal protein S18-alanine N-acetyltransferase	-
JQC68_RS10965	2171074..2171301	+	228	Protein_2119	transposase	-
JQC68_RS10970	2171381..2173060	-	1680	WP_005713398.1	DNA repair protein RecN	-
JQC68_RS10975	2173303..2173525	-	223	Protein_2121	hypothetical protein	-
JQC68_RS10980	2173535..2174377	+	843	WP_021114212.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (161-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 51059.06 Da
• Isoelectric Point: 5.3404

>T190129 WP_021113222.1 NZ_CP069308:c2170349-2169006 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLAETGMDFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Nucleotide

• Length: 1344 bp

>T190129 NZ_CP091120:4107311-4107655 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACCAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGAGTGTTTTTCGCTTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACTGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACTCGGAGGTAG

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13225.52 Da
• Isoelectric Point: 10.2782

>AT190129 WP_015940035.1 NZ_CP069308:c2169006-2168662 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Nucleotide

• Length: 345 bp

>AT190129 NZ_CP091120:4107661-4107963 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Structures

Toxin

• AlphaFold DB: A0A084EEY9