Detailed information of TA system TA190128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1942423..1943972
• Replicon: chromosome
• Accession: NZ_CP069308
• Organism: Glaesserella parasuis strain EHP1804

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JQC68_RS09770
• Protein ID: WP_160436609.1
• Coordinates: 1942423..1943739 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: U4SAZ6
• Locus tag: JQC68_RS09775
• Protein ID: WP_010786623.1
• Coordinates: 1943733..1943972 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQC68_RS09745	1937464..1939269	+	1806	WP_203399053.1	AAA family ATPase	-
JQC68_RS09750	1939377..1940249	+	873	WP_078208807.1	LysR family transcriptional regulator	-
JQC68_RS09755	1940310..1940930	-	621	WP_203399054.1	DsbA family protein	-
JQC68_RS09760	1941039..1941275	+	237	WP_021116421.1	GntR family transcriptional regulator	-
JQC68_RS09765	1941283..1942419	+	1137	WP_203399055.1	PLP-dependent aminotransferase family protein	-
JQC68_RS09770	1942423..1943739	-	1317	WP_160436609.1	type II toxin-antitoxin system HipA family toxin	Toxin
JQC68_RS09775	1943733..1943972	-	240	WP_010786623.1	helix-turn-helix domain-containing protein	Antitoxin
JQC68_RS09780	1944120..1944947	-	828	WP_203399056.1	alpha/beta hydrolase	-
JQC68_RS09785	1945078..1946523	+	1446	WP_021116416.1	metalloprotease TldD	-
JQC68_RS09790	1946777..1947187	+	411	WP_020457617.1	preprotein translocase subunit SecE	-
JQC68_RS09795	1947189..1947767	+	579	WP_020457616.1	transcription termination/antitermination protein NusG	-
JQC68_RS09800	1947877..1948423	+	547	Protein_1903	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1947877..1948347	470

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-404)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50031.25 Da
• Isoelectric Point: 7.3465

>T190128 WP_160436609.1 NZ_CP069308:c1943739-1942423 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSSYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T190128 NZ_CP091120:c3803489-3803100 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGCAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCCAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATCGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGTGAGAAAGGACAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9059.47 Da
• Isoelectric Point: 9.7684

>AT190128 WP_010786623.1 NZ_CP069308:c1943972-1943733 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT190128 NZ_CP091120:c3803756-3803493 [Serratia marcescens]
ATGGAAAGAATCGCCAAGCTGTTTAAAAACGGTAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTGTATATCCGTCGCGATCGGGAGGGAAACGTGATTTTATCCAAATATCCAGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Antitoxin

• AlphaFold DB: U4SAZ6