Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1579717..1580297 Replicon chromosome
Accession NZ_CP069308
Organism Glaesserella parasuis strain EHP1804

Toxin (Protein)


Gene name mazF Uniprot ID A0A836MFL2
Locus tag JQC68_RS07895 Protein ID WP_021114594.1
Coordinates 1579953..1580297 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag JQC68_RS07890 Protein ID WP_005710601.1
Coordinates 1579717..1579956 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC68_RS07865 1575412..1576104 - 693 WP_021114597.1 tellurite resistance TerB family protein -
JQC68_RS07870 1576175..1577023 - 849 WP_075592852.1 ABC transporter permease subunit -
JQC68_RS07875 1577020..1577805 - 786 WP_016528266.1 ABC transporter permease subunit -
JQC68_RS07880 1577795..1578547 - 753 WP_102033221.1 phosphonate ABC transporter ATP-binding protein -
JQC68_RS07885 1578656..1579531 - 876 WP_021113313.1 putative selenate ABC transporter substrate-binding protein -
JQC68_RS07890 1579717..1579956 + 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JQC68_RS07895 1579953..1580297 + 345 WP_021114594.1 endoribonuclease MazF Toxin
JQC68_RS07900 1580303..1580971 + 669 WP_021118711.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
JQC68_RS07905 1580984..1582375 + 1392 WP_010785980.1 MATE family efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12801.77 Da        Isoelectric Point: 7.3830

>T190126 WP_021114594.1 NZ_CP069308:1579953-1580297 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVDIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

>T190126 NZ_CP091120:1982954-1983050 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT190126 WP_005710601.1 NZ_CP069308:1579717-1579956 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp

>AT190126 NZ_CP091120:c1983050-1982910 [Serratia marcescens]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836MFL2

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References