Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1495901..1496436 Replicon chromosome
Accession NZ_CP069308
Organism Glaesserella parasuis strain EHP1804

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag JQC68_RS07505 Protein ID WP_010785923.1
Coordinates 1495901..1496185 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag JQC68_RS07510 Protein ID WP_021118772.1
Coordinates 1496182..1496436 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC68_RS07485 1491531..1492022 + 492 WP_005712683.1 acetolactate synthase small subunit -
JQC68_RS07490 1492129..1492950 - 822 WP_005712684.1 PHP domain-containing protein -
JQC68_RS07495 1493099..1494058 - 960 WP_203398968.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
JQC68_RS07500 1494141..1495691 - 1551 WP_021116606.1 exodeoxyribonuclease I -
JQC68_RS07505 1495901..1496185 - 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQC68_RS07510 1496182..1496436 - 255 WP_021118772.1 hypothetical protein Antitoxin
JQC68_RS07515 1496553..1497308 - 756 WP_021112098.1 ABC transporter permease -
JQC68_RS07520 1497330..1498226 - 897 WP_005712691.1 ABC transporter ATP-binding protein -
JQC68_RS07525 1498232..1500250 - 2019 WP_078208282.1 DNA polymerase III subunit gamma/tau -
JQC68_RS07530 1500340..1500882 - 543 WP_010785927.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T190125 WP_010785923.1 NZ_CP069308:c1496185-1495901 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T190125 NZ_CP091120:1563345-1563653 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCCCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT190125 WP_021118772.1 NZ_CP069308:c1496436-1496182 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT190125 NZ_CP091120:1563106-1563342 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References