Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 842052..842829 Replicon chromosome
Accession NZ_CP069308
Organism Glaesserella parasuis strain EHP1804

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A836YXW5
Locus tag JQC68_RS04455 Protein ID WP_016527794.1
Coordinates 842052..842552 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag JQC68_RS04460 Protein ID WP_005710653.1
Coordinates 842542..842829 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC68_RS04420 837178..837333 - 156 WP_021116533.1 YoaH family protein -
JQC68_RS04425 837351..838079 - 729 WP_021112446.1 tRNA pseudouridine(65) synthase TruC -
JQC68_RS04430 838076..838390 - 315 WP_203399264.1 YqcC family protein -
JQC68_RS04435 838432..839346 - 915 WP_021113663.1 N-acetylmuramic acid 6-phosphate etherase -
JQC68_RS04440 839358..840473 - 1116 WP_043894690.1 anhydro-N-acetylmuramic acid kinase -
JQC68_RS04445 840627..840962 - 336 WP_016527793.1 outer membrane protein assembly factor BamE -
JQC68_RS04450 841023..842024 - 1002 WP_021116692.1 nucleoid-associated protein YejK -
JQC68_RS04455 842052..842552 - 501 WP_016527794.1 GNAT family N-acetyltransferase Toxin
JQC68_RS04460 842542..842829 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
JQC68_RS04465 842975..843364 + 390 WP_021116694.1 RidA family protein -
JQC68_RS04470 843368..844105 + 738 WP_016527796.1 peptidoglycan editing factor PgeF -
JQC68_RS04475 844280..845857 + 1578 WP_203399265.1 FAD-binding protein -
JQC68_RS04480 845961..846461 + 501 WP_021115009.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19081.26 Da        Isoelectric Point: 9.2835

>T190122 WP_016527794.1 NZ_CP069308:c842552-842052 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T190122 NZ_CP091120:c14538-14158 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCTGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACAGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT190122 WP_005710653.1 NZ_CP069308:c842829-842542 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT190122 NZ_CP091120:c14759-14538 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCGCG
GGCCGAGATCATTCGTCAAGCAGTCTCCCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YXW5

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References