Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 422071..422684 | Replicon | chromosome |
| Accession | NZ_CP069308 | ||
| Organism | Glaesserella parasuis strain EHP1804 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | JQC68_RS02345 | Protein ID | WP_200859958.1 |
| Coordinates | 422071..422238 (+) | Length | 56 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A1T0AB61 |
| Locus tag | JQC68_RS02350 | Protein ID | WP_005714429.1 |
| Coordinates | 422277..422684 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JQC68_RS02300 | 417201..417746 | - | 546 | WP_203399203.1 | lysozyme | - |
| JQC68_RS02305 | 417721..418020 | - | 300 | WP_203399204.1 | hypothetical protein | - |
| JQC68_RS02310 | 418134..418697 | + | 564 | WP_021114960.1 | hypothetical protein | - |
| JQC68_RS02315 | 418850..419095 | - | 246 | WP_026916569.1 | hypothetical protein | - |
| JQC68_RS02320 | 419572..420159 | - | 588 | Protein_448 | phage antirepressor N-terminal domain-containing protein | - |
| JQC68_RS02325 | 420710..420895 | + | 186 | WP_021116919.1 | hypothetical protein | - |
| JQC68_RS02330 | 420904..421278 | - | 375 | WP_071610301.1 | antitermination protein | - |
| JQC68_RS02335 | 421275..421679 | - | 405 | WP_021116921.1 | RusA family crossover junction endodeoxyribonuclease | - |
| JQC68_RS02340 | 421676..421966 | - | 291 | WP_160415182.1 | DUF1364 domain-containing protein | - |
| JQC68_RS02345 | 422071..422238 | + | 168 | WP_200859958.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| JQC68_RS02350 | 422277..422684 | + | 408 | WP_005714429.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| JQC68_RS02355 | 422723..423145 | - | 423 | WP_203399332.1 | recombination protein NinB | - |
| JQC68_RS02360 | 423422..424093 | - | 672 | WP_203399205.1 | holin | - |
| JQC68_RS02365 | 424093..424878 | - | 786 | WP_203399206.1 | replication protein | - |
| JQC68_RS02370 | 424875..425513 | - | 639 | WP_203399333.1 | phage regulatory protein/antirepressor Ant | - |
| JQC68_RS02375 | 425609..425854 | - | 246 | WP_160405314.1 | hypothetical protein | - |
| JQC68_RS02380 | 425875..426081 | - | 207 | WP_012621794.1 | helix-turn-helix transcriptional regulator | - |
| JQC68_RS02385 | 426217..426870 | + | 654 | WP_005714960.1 | LexA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 397983..470095 | 72112 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 56 a.a. Molecular weight: 6272.42 Da Isoelectric Point: 11.0319
>T190121 WP_200859958.1 NZ_CP069308:422071-422238 [Glaesserella parasuis]
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
Download Length: 168 bp
>T190121 NZ_CP091110:249666-250016 [Neobacillus drentensis]
TTGATTGTCAAGCGTGGTGACGTTTATTTTGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGACCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTGATTGTTGCAGCGATTACAGCTCAAATTCAAAAAG
CAAAGCTTCCTACTCATGTCGAGATTGATGCGAAGCGCTACGGATTTGAACGTGACTCGGTCATTCTGCTAGAGCAAATT
CGTACAATTGATAAGCAGCGGTTAACCGATAAAATCACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCCT
ACAGGTAAGTTTAGGTCTCATCGAATTTTAG
TTGATTGTCAAGCGTGGTGACGTTTATTTTGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGACCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTGATTGTTGCAGCGATTACAGCTCAAATTCAAAAAG
CAAAGCTTCCTACTCATGTCGAGATTGATGCGAAGCGCTACGGATTTGAACGTGACTCGGTCATTCTGCTAGAGCAAATT
CGTACAATTGATAAGCAGCGGTTAACCGATAAAATCACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCCT
ACAGGTAAGTTTAGGTCTCATCGAATTTTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 14890.91 Da Isoelectric Point: 4.6143
>AT190121 WP_005714429.1 NZ_CP069308:422277-422684 [Glaesserella parasuis]
MLYPLIFEQVSDGYVVAVPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
MLYPLIFEQVSDGYVVAVPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
Download Length: 408 bp
>AT190121 NZ_CP091110:249380-249661 [Neobacillus drentensis]
GTGTCTGAAACTGGCGCAACTACGGAAATCTTAGTAAAGTTACCGCAACATCTTTTAACTGAGTTAGATGGTTTCGTTAA
GCAAGAAAATGTGAACCGCAGTGAGTTTATTTACCAAGCAACCAAAATGTATTTACGCGAACGGAAAAAGAGACAAATTC
GCGAGTCGATGAGACGTGGATACATGGAAATGGCTAAGATCAATCTTAGAATTGCATCAGAAGCATTTTTGGCGGAATAT
GAGGCAGAACACACAGTTGAACGTCTTGTAAGCGGAGGATAA
GTGTCTGAAACTGGCGCAACTACGGAAATCTTAGTAAAGTTACCGCAACATCTTTTAACTGAGTTAGATGGTTTCGTTAA
GCAAGAAAATGTGAACCGCAGTGAGTTTATTTACCAAGCAACCAAAATGTATTTACGCGAACGGAAAAAGAGACAAATTC
GCGAGTCGATGAGACGTGGATACATGGAAATGGCTAAGATCAATCTTAGAATTGCATCAGAAGCATTTTTGGCGGAATAT
GAGGCAGAACACACAGTTGAACGTCTTGTAAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|