Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4127223..4128076 Replicon plasmid unnamed1
Accession NZ_CP069303
Organism Shinella sp. PSBB067

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JQ506_RS21365 Protein ID WP_203317253.1
Coordinates 4127223..4127753 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JQ506_RS21370 Protein ID WP_203317254.1
Coordinates 4127741..4128076 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ506_RS21340 4122839..4123897 - 1059 WP_203317249.1 succinylglutamate desuccinylase/aspartoacylase family protein -
JQ506_RS21345 4124028..4124597 + 570 WP_203317250.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
JQ506_RS21350 4124594..4125457 - 864 WP_203317251.1 sigma-70 family RNA polymerase sigma factor -
JQ506_RS21355 4125447..4125908 - 462 WP_203317252.1 carboxymuconolactone decarboxylase family protein -
JQ506_RS21365 4127223..4127753 - 531 WP_203317253.1 GNAT family N-acetyltransferase Toxin
JQ506_RS21370 4127741..4128076 - 336 WP_203317254.1 DUF1778 domain-containing protein Antitoxin
JQ506_RS21375 4128289..4129965 - 1677 WP_203317255.1 UvrD-helicase domain-containing protein -
JQ506_RS21380 4129962..4131959 - 1998 WP_203319893.1 AAA family ATPase -
JQ506_RS21385 4132299..4132399 + 101 Protein_3885 antirestriction protein ArdA -
JQ506_RS21390 4132444..4132953 - 510 WP_203317256.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaBKC-1 htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm / ugd / kdsB / fliQ / flhA / icl 1..4605385 4605385
- flank IS/Tn - - 4126489..4126866 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(50-151)

Antitoxin

Vibrio phage ICP1, Orf50

(30-105)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19025.79 Da        Isoelectric Point: 7.7005

>T190117 WP_203317253.1 NZ_CP069303:c4127753-4127223 [Shinella sp. PSBB067]
MAEIGDTPKHSEPRLSAPVPLKAEHDLSAFDCGEPALNDWLRQRALKNESRFSRTYVVCAGNRVVGYFCISAGSVERSAA
PGKVRRNAPDLIPVSIIGRLAVSLDHAGRGLGADLLSDALRRIALASQSIGIGAVMVQAKDEAAKRFYLRCAEFIEYPED
SRTLFLPIETVVAGFG

Download         Length: 531 bp

>T190117 NZ_CP091099:c2437549-2437370 [Pantoea agglomerans]
ATGGATAGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAGGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12140.88 Da        Isoelectric Point: 10.7841

>AT190117 WP_203317254.1 NZ_CP069303:c4128076-4127741 [Shinella sp. PSBB067]
MAKTRLATSESSRSAAVAARASAADTKGSINLRIESGTRQLIDDAAAVLGKTRTEFMVESARRQAVDVLLDQRLFTLDPE
RYDAFMQALDNPPAPGPKLKALLRRTPAWQK

Download         Length: 336 bp

>AT190117 NZ_CP091099:c2437343-2436918 [Pantoea agglomerans]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGTTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCCGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References