Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 485644..486185 Replicon plasmid unnamed1
Accession NZ_CP069303
Organism Shinella sp. PSBB067

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JQ506_RS04045 Protein ID WP_203318096.1
Coordinates 485862..486185 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JQ506_RS04040 Protein ID WP_203318095.1
Coordinates 485644..485865 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ506_RS04010 480825..481445 + 621 WP_203318089.1 pyridoxamine 5'-phosphate oxidase -
JQ506_RS04015 481442..481828 + 387 WP_203318090.1 nuclear transport factor 2 family protein -
JQ506_RS04020 481833..482888 - 1056 WP_203318091.1 polysaccharide deacetylase family protein -
JQ506_RS04025 482925..483068 - 144 WP_203318092.1 hypothetical protein -
JQ506_RS04030 483157..484044 + 888 WP_203318093.1 LysR family transcriptional regulator -
JQ506_RS04035 484048..485463 - 1416 WP_203318094.1 metalloprotease TldD -
JQ506_RS04040 485644..485865 + 222 WP_203318095.1 antitoxin MazE family protein Antitoxin
JQ506_RS04045 485862..486185 + 324 WP_203318096.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JQ506_RS04050 486190..486720 - 531 WP_203318097.1 invasion associated locus B family protein -
JQ506_RS04055 487126..488010 + 885 WP_203318098.1 cytochrome c oxidase subunit II -
JQ506_RS04060 488030..489697 + 1668 WP_203318099.1 cytochrome c oxidase subunit I -
JQ506_RS04065 489949..490893 + 945 WP_203318100.1 heme o synthase -
JQ506_RS04070 490893..491033 + 141 WP_203318101.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaBKC-1 htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm / ugd / kdsB / fliQ / flhA / icl 1..4605385 4605385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(7-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11375.36 Da        Isoelectric Point: 10.0901

>T190116 WP_203318096.1 NZ_CP069303:485862-486185 [Shinella sp. PSBB067]
VKRGDFVIVAIQGDFGKPRPALVIQSDLFSEAATVTVLMVSSTLQDAPLLRIPVEPSVGNGLGKSSQIMVDKAMTIRRDK
IGKVIGTLDTETMASVTRSLALFLGFA

Download         Length: 324 bp

>T190116 NZ_CP091099:2182710-2182925 [Pantoea agglomerans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8330.52 Da        Isoelectric Point: 9.4013

>AT190116 WP_203318095.1 NZ_CP069303:485644-485865 [Shinella sp. PSBB067]
MAKAVSERVQKRRNALRANGLRPVQMWLPDTRRIGFAEECVRQARKIAVAETDDRDLDRFLDAAFLDLVGSDT

Download         Length: 222 bp

>AT190116 NZ_CP091099:2182308-2182685 [Pantoea agglomerans]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGTCTGTTTGACGACAGCATGGC
AACATTAACCGACAGTCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References