Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 402900..403780 Replicon chromosome
Accession NZ_CP069278
Organism Bifidobacterium longum strain HN001

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag JQN89_RS02070 Protein ID WP_007052625.1
Coordinates 402900..403391 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag JQN89_RS02075 Protein ID WP_013410773.1
Coordinates 403388..403780 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN89_RS02050 397979..399209 + 1231 Protein_399 sensor histidine kinase -
JQN89_RS02055 399244..399963 + 720 WP_203385606.1 response regulator transcription factor -
JQN89_RS02060 400003..400644 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
JQN89_RS02065 400734..402839 + 2106 WP_032736308.1 DUF262 domain-containing protein -
JQN89_RS02070 402900..403391 - 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
JQN89_RS02075 403388..403780 - 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JQN89_RS02080 403925..406624 - 2700 WP_101011236.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T190112 WP_007052625.1 NZ_CP069278:c403391-402900 [Bifidobacterium longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T190112 NZ_CP091099:672640-672993 [Pantoea agglomerans]
GTGTGGATGATTAAAACGACGGAGAGGTTTGATCGCTGGTTTACCTTGCTTAATGAGAGCGATCGCGCCTGCGTACTGGC
AGCATTAATGGTGTTGCGCGAAAAGGGGCCGGGGTTGTCCAGGCCATACGCGGATACGCTAAAAGGCTCTGTTTATATCA
ACATGAAAGAGCTGCGTATTCAGAGTCGCGGCGATCCGATAAGGGCTTTCTTTGCTTTTGACCCAAACCGAACGGCGATT
GTGCTTTGTGCCGGAAATAAGGTGGGCAATGAAAAGCGTTTTTATCAGGAGATGCTTCCGGTTGCCGATCGGGAATTTAC
ACACTGGCTGAATAGTTTTAAAGATGAGGAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT190112 WP_013410773.1 NZ_CP069278:c403780-403388 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT190112 NZ_CP091099:672998-673300 [Pantoea agglomerans]
ATGGGCAGAACGCTTGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCGATGGCGACGGATAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGCGAGAAAGTGCAGAAAACACAGGTCGAAATGGCAAAGGCGCTGGGCATTA
CACAGCCTACCGTGGCGGGCATGGAGAAGCCGGGCCGCGACCTGAAGCTCTCCACGCTCAAGCGCTATATCGATGCGGCA
GGGGGTAAGCTGCGGCTGGTGGTGGAACTGCCGGACGGCTCGCACTACGGGTTTGAGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References