Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 929567..930096 Replicon chromosome
Accession NZ_CP069219
Organism Staphylococcus epidermidis strain Z0118SE0272

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag JQC90_RS04420 Protein ID WP_001829891.1
Coordinates 929734..930096 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag JQC90_RS04415 Protein ID WP_001829931.1
Coordinates 929567..929737 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC90_RS04390 925392..925871 + 480 WP_001829909.1 PH domain-containing protein -
JQC90_RS04395 925864..927369 + 1506 WP_001829976.1 PH domain-containing protein -
JQC90_RS04400 927356..927865 + 510 WP_001829888.1 PH domain-containing protein -
JQC90_RS04405 927913..928266 + 354 WP_001829915.1 holo-ACP synthase -
JQC90_RS04410 928332..929480 + 1149 WP_001829972.1 alanine racemase -
JQC90_RS04415 929567..929737 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JQC90_RS04420 929734..930096 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JQC90_RS04425 930442..931443 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
JQC90_RS04430 931543..931869 + 327 WP_001829952.1 anti-sigma factor antagonist -
JQC90_RS04435 931871..932350 + 480 WP_001829903.1 anti-sigma B factor RsbW -
JQC90_RS04440 932325..933095 + 771 WP_001829937.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T190104 WP_001829891.1 NZ_CP069219:929734-930096 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T190104 NZ_CP091088:c1147294-1147016 [Pseudomonas juntendi]
ATGATTCAAAGCTTCAGCTGTGCCGACACGGAAGCACTATTTGTTACTGGAAAAACGCGACGTTGGTCAGATATCAAATC
AGTCGCGGAGCGCAAACTGGCCATGCTCGATGCCGCAACAGAGCTGCGAGACCTGCGATCGCCACCTGGCAACCGCCTCG
AGGCGTTGAGCGGCAACCGTGCCGGTCAGCACAGCATTCGCGTCAATGACCAATGGCGCTTGTGCTTCACCTGGACCGAC
AACGGGCCGGCCAACGTTGAAATTATCGATTACCACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT190104 WP_001829931.1 NZ_CP069219:929567-929737 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT190104 NZ_CP091088:c1147007-1146708 [Pseudomonas juntendi]
ATGCTCAAGAACGGTATGCGTCCAATCCATCCCGGTGAAGTCCTGCGTGAGGACTTCCAGAAAGAAATGGGCTTCAGTGC
TGCGGCATTGGCCAGGGCGCTGGGCGTCGCCACTCCAACCGTCAACAATATCCTGCGCGAACGGGGCGGTGTTTCCGCCG
ATATGGCGCTGCGTCTGTCCATTTGCCTGGATACTACCCCCGAGTTCTGGCTCAACCTGCAGACCGCCTTCGATCTGCGC
ACCGCCGAACAGCGACACGGTGAAGAGATCATCGGGGCGGTACAGCGCCTGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References