Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 918384..918893 Replicon chromosome
Accession NZ_CP069219
Organism Staphylococcus epidermidis strain Z0118SE0272

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag JQC90_RS04360 Protein ID WP_001829980.1
Coordinates 918684..918893 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag JQC90_RS04355 Protein ID WP_001829893.1
Coordinates 918384..918677 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC90_RS04330 913392..914180 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
JQC90_RS04335 914186..914824 + 639 WP_002505076.1 thiamine phosphate synthase -
JQC90_RS04340 914913..915785 + 873 WP_001832740.1 membrane protein insertase YidC -
JQC90_RS04345 915891..916544 - 654 WP_001829983.1 HD domain-containing protein -
JQC90_RS04350 916726..918210 - 1485 WP_001829964.1 cardiolipin synthase -
JQC90_RS04355 918384..918677 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
JQC90_RS04360 918684..918893 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
JQC90_RS04365 919036..919173 + 138 WP_001829949.1 hypothetical protein -
JQC90_RS04370 919273..920484 - 1212 WP_001829910.1 rod shape-determining protein RodA -
JQC90_RS04375 920875..921948 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
JQC90_RS04380 921960..923315 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T190103 WP_001829980.1 NZ_CP069219:918684-918893 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T190103 NZ_CP091087:c266972-266721 [Corynebacterium pseudodiphtheriticum]
ATGAAAACCATGTCTTATTCCGATTCACGAGCACACTATGCAGAGATGCTTGATACCGTGACTGATGATCGTGAAGAAGT
CATCATTACACGCGCAGGACATGAGCCGGTAGTGGTCGTCTCCCTTGATGATTATGAATCATTAAAAGAAACCGCATACC
TGCTCAAAAGCCCGGCTAATGCTCGCCGACTACTAGCCTCAATTGAACAGCTCGAAAATGGCGAAGGCACTCAACGGGAT
TTACTCGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT190103 WP_001829893.1 NZ_CP069219:918384-918677 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT190103 NZ_CP091087:c266724-266464 [Corynebacterium pseudodiphtheriticum]
ATGAAACTAGTCTGGACTGAATCAGCCTGGGAGGATTACACCTGGTGGCAGACTGAAGACCGGAAGGTGCTCAAACGCAT
CAACAGATTAATCAAAGAGATTCAACGAAATGGAAACTCCGGCATCGGCAAACCAGAACCACTCAAACACGGATTTCAGG
GCTATTGGTCTCGGAGAATCACAGATGAGCACCGGATAGTTTATAAAATTTTCGGCAATGAACTTCGCATTGCTTCCTGC
CGATACCACTATGGGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References