Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_26(antitoxin)
Location 779412..780188 Replicon chromosome
Accession NZ_CP069219
Organism Staphylococcus epidermidis strain Z0118SE0272

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JQC90_RS03530 Protein ID WP_203267731.1
Coordinates 779412..779864 (-) Length 151 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JQC90_RS03535 Protein ID WP_053091513.1
Coordinates 779877..780188 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC90_RS03500 774592..775569 + 978 WP_001829784.1 tagatose-bisphosphate aldolase -
JQC90_RS03505 775589..775903 + 315 WP_001829758.1 PTS lactose/cellobiose transporter subunit IIA -
JQC90_RS03510 775909..776796 + 888 Protein_698 PTS transporter subunit EIIC -
JQC90_RS03515 776809..778200 - 1392 WP_203267729.1 recombinase family protein -
JQC90_RS03520 778259..778882 - 624 WP_203267730.1 hypothetical protein -
JQC90_RS03525 778884..779408 - 525 WP_002502889.1 hypothetical protein -
JQC90_RS03530 779412..779864 - 453 WP_203267731.1 ImmA/IrrE family metallo-endopeptidase Toxin
JQC90_RS03535 779877..780188 - 312 WP_053091513.1 helix-turn-helix domain-containing protein Antitoxin
JQC90_RS03540 780357..780575 + 219 WP_047499919.1 hypothetical protein -
JQC90_RS03545 780614..781060 + 447 WP_203267732.1 hypothetical protein -
JQC90_RS03550 781073..781249 + 177 WP_176293859.1 hypothetical protein -
JQC90_RS03555 781293..782066 + 774 WP_203267733.1 phage antirepressor KilAC domain-containing protein -
JQC90_RS03560 782108..782341 + 234 WP_203267734.1 DUF2829 domain-containing protein -
JQC90_RS03565 782551..782691 + 141 WP_203267735.1 hypothetical protein -
JQC90_RS03570 782783..782956 + 174 WP_203267736.1 DUF1270 family protein -
JQC90_RS03575 782959..783255 + 297 WP_203267737.1 XRE family transcriptional regulator -
JQC90_RS03580 783329..783604 + 276 WP_203267738.1 chordopoxvirus fusion protein -
JQC90_RS03585 783576..783803 + 228 WP_203267739.1 DUF2483 family protein -
JQC90_RS03590 783796..784416 + 621 WP_203267740.1 DUF1071 domain-containing protein -
JQC90_RS03595 784416..784844 + 429 WP_203077590.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 765877..819916 54039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 17697.21 Da        Isoelectric Point: 5.2819

>T190102 WP_203267731.1 NZ_CP069219:c779864-779412 [Staphylococcus epidermidis]
VGKYEDLMIKYDHLPITETKYMPDFMSGLYLDGEILINDNRSVRQKLEILAEEIAHHEITYGNILNINDFQNNKYELKAR
RLAFEMLVGLDDLVIAHNEGVKNTYELSEFFEVTEQFIKDCLKHYKTKHGNKVKHDNYLITFEPLNVKEI

Download         Length: 453 bp

>T190102 NZ_CP091087:c266724-266464 [Corynebacterium pseudodiphtheriticum]
ATGAAACTAGTCTGGACTGAATCAGCCTGGGAGGATTACACCTGGTGGCAGACTGAAGACCGGAAGGTGCTCAAACGCAT
CAACAGATTAATCAAAGAGATTCAACGAAATGGAAACTCCGGCATCGGCAAACCAGAACCACTCAAACACGGATTTCAGG
GCTATTGGTCTCGGAGAATCACAGATGAGCACCGGATAGTTTATAAAATTTTCGGCAATGAACTTCGCATTGCTTCCTGC
CGATACCACTATGGGCGTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12230.89 Da        Isoelectric Point: 5.3506

>AT190102 WP_053091513.1 NZ_CP069219:c780188-779877 [Staphylococcus epidermidis]
MSIGNRIKKRRKEMKMSADKLAEKIGKNRATVYRYEKDEIENMPYDVLEPIAEALNVSPAYLMGWEEKEKTETVAAHLDY
SDLTEEEQKEVENFIDYIRNRRK

Download         Length: 312 bp

>AT190102 NZ_CP091087:c266972-266721 [Corynebacterium pseudodiphtheriticum]
ATGAAAACCATGTCTTATTCCGATTCACGAGCACACTATGCAGAGATGCTTGATACCGTGACTGATGATCGTGAAGAAGT
CATCATTACACGCGCAGGACATGAGCCGGTAGTGGTCGTCTCCCTTGATGATTATGAATCATTAAAAGAAACCGCATACC
TGCTCAAAAGCCCGGCTAATGCTCGCCGACTACTAGCCTCAATTGAACAGCTCGAAAATGGCGAAGGCACTCAACGGGAT
TTACTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References