Detailed information of TA system TA190101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1877337..1878133
• Replicon: chromosome
• Accession: NZ_CP069215
• Organism: Staphylococcus epidermidis strain Z0118SE0269

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JQC88_RS08960
• Protein ID: WP_203263005.1
• Coordinates: 1877672..1878133 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JQC88_RS08955
• Protein ID: WP_203263004.1
• Coordinates: 1877337..1877660 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQC88_RS08920	1872891..1874843	-	1953	WP_203262997.1	AAA family ATPase	-
JQC88_RS08925	1874905..1875081	-	177	WP_203262998.1	hypothetical protein	-
JQC88_RS08930	1875195..1875437	+	243	WP_203262999.1	hypothetical protein	-
JQC88_RS08935	1875574..1875783	-	210	WP_001830281.1	hypothetical protein	-
JQC88_RS08940	1875796..1876536	-	741	WP_203263001.1	ORF6C domain-containing protein	-
JQC88_RS08945	1876594..1876779	+	186	WP_203263003.1	hypothetical protein	-
JQC88_RS08950	1876927..1877174	-	248	Protein_1730	helix-turn-helix transcriptional regulator	-
JQC88_RS08955	1877337..1877660	+	324	WP_203263004.1	helix-turn-helix domain-containing protein	Antitoxin
JQC88_RS08960	1877672..1878133	+	462	WP_203263005.1	ImmA/IrrE family metallo-endopeptidase	Toxin
JQC88_RS08965	1878150..1878668	+	519	WP_203263006.1	hypothetical protein	-
JQC88_RS08970	1878670..1879440	+	771	Protein_1734	DUF5067 domain-containing protein	-
JQC88_RS08975	1879652..1880089	+	438	WP_099800570.1	DUF4231 domain-containing protein	-
JQC88_RS08980	1880083..1880490	+	408	WP_099800569.1	TIR domain-containing protein	-
JQC88_RS08985	1880487..1880684	-	198	WP_002497576.1	hypothetical protein	-
JQC88_RS08990	1880796..1881845	+	1050	WP_134299676.1	site-specific integrase	-
JQC88_RS09005	1882246..1882821	-	576	WP_001829272.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1836552..1881845	45293

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (32-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18305.97 Da
• Isoelectric Point: 6.1480

>T190101 WP_203263005.1 NZ_CP069215:1877672-1878133 [Staphylococcus epidermidis]
MGLYEKMLIEHDYIEVRETNVMPNNLHGLWLGDLILIKRNLSEIRKAEVLYEELAHHKLTYGNILDQSKDINRKFENYAR
RYGYEAALPLRIIVEAHNYGVSNLYELAEYVQLSEEYIAEILKHYKNKYGIGTHYEEYLITFDPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T190101 NZ_CP091084:32139-32489 [Enterobacter roggenkampii]
ATGTGGACAGTAAAAACGACCTCTCTATTCGATGTCTGGTTTGATGAACAAGACGAGGCCACGCAGGAGAAGGTTTTGGC
TGGGTTGCTTGCCTTGGCACAGGGCGGTCCATCGGTAGGGCGACCCTTAGTTGATACCATCAAGGGATCTCGCTTTACGA
ACCTTAAAGAGCTGAGAGTTCAGCACCAGGGGGATCCGCTACGAGCGTTCTTTGCTTTTGACCCGTTGCGGCAAGCTATC
GTGTTGTGTGCTGGAAATAAGGGCGGTAACGATAAGCGGTTTTACAAAGAGATGTTGCCGGTCGCTGAGGCGGAATACGC
CAAGCACTTAACTGAGTTGGAGGTAGGGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12338.05 Da
• Isoelectric Point: 9.4439

>AT190101 WP_203263004.1 NZ_CP069215:1877337-1877660 [Staphylococcus epidermidis]
MRTSAEIGKLIKQLRKENNINLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALNVTPESLLLKNKQPETEIQHRA
AHLEAELTDDEWKRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT190101 NZ_CP091084:32489-32791 [Enterobacter roggenkampii]
ATGGGAAGAACACTGAATGAGATGCTGGCCTCCCGCTCGGTGGATAGTCAGCAGCGGATCCAGGAGATGGCTAACGAGCT
GCTGCTGGAGGTACGCTTGCAAGCGCTGCGTGAAGAGTTGGAAGTGTCCCAGGTGGAGTTGGCCTCTGCCCTCGGGATCA
GCCAACCGGCCGTTGTGGCGATGGAGCAGCGTGGGAATGATATCAAGCTATCCACCATGAAGCGTTACGTGGAAGCAATG
GGTGGGAAGCTGCGTGTTGATGTTGAGCTTCCTACAGGGAGGCATGTCGGTTTCAACGTCTAA