Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 818264..818793 Replicon chromosome
Accession NZ_CP069215
Organism Staphylococcus epidermidis strain Z0118SE0269

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag JQC88_RS03815 Protein ID WP_001829891.1
Coordinates 818431..818793 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag JQC88_RS03810 Protein ID WP_001829931.1
Coordinates 818264..818434 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC88_RS03785 814088..814567 + 480 WP_002457111.1 PH domain-containing protein -
JQC88_RS03790 814560..816065 + 1506 WP_002457110.1 PH domain-containing protein -
JQC88_RS03795 816052..816561 + 510 WP_002457109.1 PH domain-containing protein -
JQC88_RS03800 816609..816962 + 354 WP_002457108.1 holo-ACP synthase -
JQC88_RS03805 817029..818177 + 1149 WP_002457107.1 alanine racemase -
JQC88_RS03810 818264..818434 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JQC88_RS03815 818431..818793 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JQC88_RS03820 819138..820139 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
JQC88_RS03825 820239..820565 + 327 WP_001829952.1 anti-sigma factor antagonist -
JQC88_RS03830 820567..821046 + 480 WP_001829903.1 anti-sigma B factor RsbW -
JQC88_RS03835 821021..821791 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T190099 WP_001829891.1 NZ_CP069215:818431-818793 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T190099 NZ_CP091081:3632026-3632244 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT190099 WP_001829931.1 NZ_CP069215:818264-818434 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT190099 NZ_CP091081:3631624-3631998 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References