Detailed information of TA system TA190098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 807080..807589
• Replicon: chromosome
• Accession: NZ_CP069215
• Organism: Staphylococcus epidermidis strain Z0118SE0269

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q5HMD5
• Locus tag: JQC88_RS03755
• Protein ID: WP_001829980.1
• Coordinates: 807380..807589 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: Q5HMD4
• Locus tag: JQC88_RS03750
• Protein ID: WP_001829893.1
• Coordinates: 807080..807373 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQC88_RS03725	802088..802876	+	789	WP_001829971.1	hydroxyethylthiazole kinase	-
JQC88_RS03730	802882..803520	+	639	WP_002505076.1	thiamine phosphate synthase	-
JQC88_RS03735	803609..804481	+	873	WP_002458703.1	membrane protein insertase YidC	-
JQC88_RS03740	804587..805240	-	654	WP_001829983.1	HD domain-containing protein	-
JQC88_RS03745	805422..806906	-	1485	WP_002457116.1	cardiolipin synthase	-
JQC88_RS03750	807080..807373	+	294	WP_001829893.1	copper-sensing transcriptional repressor CsoR	Antitoxin
JQC88_RS03755	807380..807589	+	210	WP_001829980.1	heavy-metal-associated domain-containing protein	Toxin
JQC88_RS03760	807732..807869	+	138	WP_001829949.1	hypothetical protein	-
JQC88_RS03765	807968..809179	-	1212	WP_002486299.1	rod shape-determining protein RodA	-
JQC88_RS03770	809570..810643	+	1074	WP_002468311.1	D-alanine--D-alanine ligase	-
JQC88_RS03775	810655..812010	+	1356	WP_002457113.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (4-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7987.24 Da
• Isoelectric Point: 7.0080

>T190098 WP_001829980.1 NZ_CP069215:807380-807589 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Nucleotide

• Length: 210 bp

>T190098 NZ_CP091081:3128468-3128941 [Enterobacter roggenkampii]
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGGGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCTGAGGACTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTGTATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11070.65 Da
• Isoelectric Point: 5.5778

>AT190098 WP_001829893.1 NZ_CP069215:807080-807373 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT190098 NZ_CP091081:3128028-3128471 [Enterobacter roggenkampii]
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGTGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTCGGGAACGTGGCGCCCGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTAATTGGCCGCCTGGAACACGGCGTGTTCGCATGA

Structures

Toxin

• AlphaFold DB: A0A2G7HWU1

Antitoxin

• AlphaFold DB: A0A0N1EPA7