Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 807080..807589 Replicon chromosome
Accession NZ_CP069215
Organism Staphylococcus epidermidis strain Z0118SE0269

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag JQC88_RS03755 Protein ID WP_001829980.1
Coordinates 807380..807589 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag JQC88_RS03750 Protein ID WP_001829893.1
Coordinates 807080..807373 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC88_RS03725 802088..802876 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
JQC88_RS03730 802882..803520 + 639 WP_002505076.1 thiamine phosphate synthase -
JQC88_RS03735 803609..804481 + 873 WP_002458703.1 membrane protein insertase YidC -
JQC88_RS03740 804587..805240 - 654 WP_001829983.1 HD domain-containing protein -
JQC88_RS03745 805422..806906 - 1485 WP_002457116.1 cardiolipin synthase -
JQC88_RS03750 807080..807373 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
JQC88_RS03755 807380..807589 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
JQC88_RS03760 807732..807869 + 138 WP_001829949.1 hypothetical protein -
JQC88_RS03765 807968..809179 - 1212 WP_002486299.1 rod shape-determining protein RodA -
JQC88_RS03770 809570..810643 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
JQC88_RS03775 810655..812010 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T190098 WP_001829980.1 NZ_CP069215:807380-807589 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T190098 NZ_CP091081:3128468-3128941 [Enterobacter roggenkampii]
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGGGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCTGAGGACTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTGTATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT190098 WP_001829893.1 NZ_CP069215:807080-807373 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT190098 NZ_CP091081:3128028-3128471 [Enterobacter roggenkampii]
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGTGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTCGGGAACGTGGCGCCCGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTAATTGGCCGCCTGGAACACGGCGTGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References