Detailed information of TA system TA190090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4944841..4946522
• Replicon: chromosome
• Accession: NZ_CP069203
• Organism: Klebsiella pneumoniae strain SP968

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: IEE96_RS24130
• Protein ID: WP_015959269.1
• Coordinates: 4944841..4945716 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: IEE96_RS24135
• Protein ID: WP_004177809.1
• Coordinates: 4945764..4946522 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEE96_RS24110 (4940147)	4940147..4941667	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
IEE96_RS24115 (4941664)	4941664..4942662	+	999	WP_002885172.1	ribose ABC transporter permease	-
IEE96_RS24120 (4942693)	4942693..4943634	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
IEE96_RS24125 (4943709)	4943709..4944716	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
IEE96_RS24130 (4944841)	4944841..4945716	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IEE96_RS24135 (4945764)	4945764..4946522	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IEE96_RS24140 (4946608)	4946608..4947336	-	729	WP_032413197.1	response regulator transcription factor	-
IEE96_RS24145 (4947609)	4947609..4949756	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
IEE96_RS24150 (4949915)	4949915..4951278	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T190090 WP_015959269.1 NZ_CP069203:c4945716-4944841 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T190090 NZ_CP091078:c5042156-5041875 [Xanthomonas arboricola pv. pruni]
ATGATCAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGCTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATTGTTGATTACCACTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT190090 WP_004177809.1 NZ_CP069203:c4946522-4945764 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT190090 NZ_CP091078:c5041857-5041567 [Xanthomonas arboricola pv. pruni]
ATGACAGTCCTACCCAACATCCACCCCGGGGAAATCCTGCTTGAGGAGTTCCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCTACCGATGTACCGCCGCGTCGCATCAACGAGATCGTCCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTAGCTGCAGCGCTGGGCACGACCGAGCGGTTCTGGCTGGGACTACAAGCCGATTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATCTGCCGTCGCGGATCAAGCGGCTGGCGGCTTGA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05