Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4783654..4784170 Replicon chromosome
Accession NZ_CP069203
Organism Klebsiella pneumoniae strain SP968

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag IEE96_RS23310 Protein ID WP_009486548.1
Coordinates 4783654..4783938 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IEE96_RS23315 Protein ID WP_002886901.1
Coordinates 4783928..4784170 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEE96_RS23285 (4779071) 4779071..4779334 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
IEE96_RS23290 (4779464) 4779464..4779637 + 174 WP_032433782.1 hypothetical protein -
IEE96_RS23295 (4779640) 4779640..4780383 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IEE96_RS23300 (4780740) 4780740..4782878 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IEE96_RS23305 (4783186) 4783186..4783650 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IEE96_RS23310 (4783654) 4783654..4783938 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IEE96_RS23315 (4783928) 4783928..4784170 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IEE96_RS23320 (4784248) 4784248..4786158 - 1911 WP_009486549.1 PRD domain-containing protein -
IEE96_RS23325 (4786181) 4786181..4787335 - 1155 WP_002886900.1 lactonase family protein -
IEE96_RS23330 (4787402) 4787402..4788142 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T190089 WP_009486548.1 NZ_CP069203:c4783938-4783654 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T190089 NZ_CP091078:c4711436-4711284 [Xanthomonas arboricola pv. pruni]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT190089 WP_002886901.1 NZ_CP069203:c4784170-4783928 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT190089 NZ_CP091078:c4711201-4711067 [Xanthomonas arboricola pv. pruni]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References