Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4679853..4680663 Replicon chromosome
Accession NZ_CP069203
Organism Klebsiella pneumoniae strain SP968

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag IEE96_RS22780 Protein ID WP_002887280.1
Coordinates 4679853..4680386 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag IEE96_RS22785 Protein ID WP_002887278.1
Coordinates 4680397..4680663 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEE96_RS22775 (4678685) 4678685..4679806 + 1122 WP_009309849.1 cupin domain-containing protein -
IEE96_RS22780 (4679853) 4679853..4680386 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
IEE96_RS22785 (4680397) 4680397..4680663 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
IEE96_RS22790 (4680766) 4680766..4682199 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
IEE96_RS22795 (4682189) 4682189..4682872 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
IEE96_RS22800 (4683045) 4683045..4684430 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
IEE96_RS22805 (4684448) 4684448..4684753 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T190088 WP_002887280.1 NZ_CP069203:c4680386-4679853 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T190088 NZ_CP091078:c4711201-4711067 [Xanthomonas arboricola pv. pruni]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT190088 WP_002887278.1 NZ_CP069203:c4680663-4680397 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT190088 NZ_CP091078:c4711436-4711284 [Xanthomonas arboricola pv. pruni]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References