Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4052029..4052648 Replicon chromosome
Accession NZ_CP069203
Organism Klebsiella pneumoniae strain SP968

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IEE96_RS19785 Protein ID WP_002892050.1
Coordinates 4052430..4052648 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IEE96_RS19780 Protein ID WP_002892066.1
Coordinates 4052029..4052403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEE96_RS19770 (4047181) 4047181..4048374 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IEE96_RS19775 (4048397) 4048397..4051543 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IEE96_RS19780 (4052029) 4052029..4052403 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IEE96_RS19785 (4052430) 4052430..4052648 + 219 WP_002892050.1 HHA domain-containing protein Toxin
IEE96_RS19790 (4052811) 4052811..4053377 + 567 WP_002892030.1 maltose O-acetyltransferase -
IEE96_RS19795 (4053349) 4053349..4053489 - 141 WP_004147370.1 hypothetical protein -
IEE96_RS19800 (4053510) 4053510..4053980 + 471 WP_020802585.1 YlaC family protein -
IEE96_RS19805 (4053955) 4053955..4055406 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
IEE96_RS19810 (4055507) 4055507..4056205 + 699 WP_023287311.1 GNAT family protein -
IEE96_RS19815 (4056202) 4056202..4056342 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IEE96_RS19820 (4056342) 4056342..4056605 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T190087 WP_002892050.1 NZ_CP069203:4052430-4052648 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T190087 NZ_CP091078:72901-73170 [Xanthomonas arboricola pv. pruni]
GTGGCCGACCTGGACGCGATTGCCGACTACATTGCGCTTGAGGACGCTGCCGCCGCAGCGGCACTGGTGAGACGGGTGTT
TGCGCATGTCGAGCAATTGGCCGAACACCCGGAGAGTGGAAGCCGGCCGCAGGAGCTCAAGCGCTCCCGCTACCGTCAAA
TCGTCGAGCCACCTTGCCGCGTGTTCTACCGTGTGGACGGGCAACGCGTTGTCGTGGTTCACGTGATGCGCTCGGAGCGG
TTACTTCGGAAGAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT190087 WP_002892066.1 NZ_CP069203:4052029-4052403 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT190087 NZ_CP091078:72626-72883 [Xanthomonas arboricola pv. pruni]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGGCAGGCCACCGAGCTCCTCGCAGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATCACCCAGCATGGCCTGCCCAGCGCATACCTGGTGGACGTCGCCAGCTATGAACGCATGCAACAGCGCATGGCGA
TCCTCGAAGGAATTGCCCGTGGTGAAATGGCGGTAGCCGAAGGCCGCAGCCTGAGCCACGAGCAAGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References